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Provisional Guideline Recommendation for EGFR Gene Mutation Testing in Liquid Samples of Lung Cancer Patients: A Proposal by the Korean Cardiopulmonary Pathology Study Group

Authors
 Dong Hoon Shin  ;  Hyo Sup Shim  ;  Tae Jung Kim  ;  Heae Surng Park  ;  Yun La Choi  ;  Wan Seop Kim  ;  Lucia Kim  ;  Sun Hee Chang  ;  Joon Seon Song  ;  Hyo jin Kim  ;  Jung Ho Han  ;  Chang Hun Lee  ;  Geon Kook Lee  ;  Se Jin Jang  ;  Korean Cardiopulmonary Pathology Study Group 
Citation
 JOURNAL OF PATHOLOGY AND TRANSLATIONAL MEDICINE, Vol.53(3) : 153-158, 2019 
Journal Title
 JOURNAL OF PATHOLOGY AND TRANSLATIONAL MEDICINE 
ISSN
 2383-7837 
Issue Date
2019
Keywords
Carcinoma, non-small-cell lung ; Circulating tumor DNA ; Epidermal growth factor receptor ;  Liquid biopsy ; T790M
Abstract
Liquid biopsy for detection of mutation from circulating tumor DNA is a new technology which is attractive in that it is non-invasive. Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKI) is an effective first line drug for advanced non-small cell lung cancer patientswho harbor activating EGFR mutation. During the course of treatment, resistance against TKI arises which can be contributed to EGFR T790M mutation in about 50-60% of patients. Third generation TKI may overcome the resistance. In patients who cannot undergo tissue biopsy due to variable reasons, liquid biopsy is an excellent alternative for the detection of EGFRT790M mutation. However, this relatively novel method requires standardization and vigorous quality insurance. Thus, a standard set of guideline recommendations for liquid biopsy for EGFR mutation testing suitable for the Korean medical community is necessary. In this article, we propose a set of provisional guideline recommendations that was discussed and approved by the Cardiopulmonary Pathology Study Group of the Korean Society of Pathologists.
Files in This Item:
T201902313.pdf Download
DOI
10.4132/jptm.2019.02.22
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
Yonsei Authors
Shim, Hyo Sup(심효섭) ORCID logo https://orcid.org/0000-0002-5718-3624
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/170428
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