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Effect of home-based transcranial direct current stimulation (tDCS) on cognitive function in patients with mild cognitive impairment: a study protocol for a randomized, double-blind, cross-over study

 Jaesub Park  ;  Yoonkyung Oh  ;  Kyungmi Chung  ;  Kwang Joon Kim  ;  Chang Oh Kim  ;  Jin Young Park 
 TRIALS, Vol.20(1) : 278, 2019 
Journal Title
Issue Date
Brain stimulation ;  Cross-over study ;  Home-based ;  Mild cognitive impairment ;  Transcranialdirect current stimulation
BACKGROUND: The possible effect of transcranial direct current stimulation (tDCS) in improving cognitive function is clear from studies involving pre-dementia stage mild cognitive impairment (MCI). However, the application of tDCS in actual clinical practice entails repeated hospital visits almost every day for treatment. The objective of this study is to confirm the possibility of self-application of tDCS at home by elderly patients with declined cognitive function and the significant clinical effect of tDCS administered at home. METHODS/DESIGN: This study will be conducted in 20 elderly people aged 60 to 80 years with complaints of subjective memory impairment while maintaining general functions with limited activities of daily living. This study involves a cross-over design that will include 2-week active or sham stimulation of both dorsolateral prefrontal cortexes (left, anode; right, cathode) randomly with a 2-week wash-out phase. Changes in cognitive function will be evaluated using visual recognition tasks and neuropsychological tests. In this study, tDCS will be carried out by each patient at his/her home and its safety and suitability will be evaluated. DISCUSSION: In this study, patients will apply a portable tDCS, developed for home use, for more than 2 weeks. Such studies can contribute to the use of tDCS as a realistic therapy. In addition, the utility of home-based tDCS will be confirmed by application of tDCS at home by the elderly with declined cognitive function. Furthermore, confirmation of tDCS as a significant therapeutic method can facilitate treatment of Alzheimer's dementia at an early stage, including MCI. TRIAL REGISTRATION: Clinical Research Information Service (CRIS), KCT0002721 . Registered on 9 March 2018.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Kwang Joon(김광준) ORCID logo https://orcid.org/0000-0002-5554-8255
Kim, Chang Oh(김창오) ORCID logo https://orcid.org/0000-0002-0773-5443
Park, Jaesub(박재섭)
Park, Jin Young(박진영) ORCID logo https://orcid.org/0000-0002-5351-9549
Chung, Kyungmi(정경미) ORCID logo https://orcid.org/0000-0003-2754-7631
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