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Therapeutic implications of cancer epithelial-mesenchymal transition (EMT)

Authors
 Eunae Sandra Cho  ;  Hee Eun Kang  ;  Nam Hee Kim  ;  Jong In Yook 
Citation
 ARCHIVES OF PHARMACAL RESEARCH, Vol.42(1) : 14-24, 2019 
Journal Title
 ARCHIVES OF PHARMACAL RESEARCH 
ISSN
 0253-6269 
Issue Date
2019
MeSH
Animals ; Antineoplastic Agents/administration & dosage ; Antineoplastic Agents/metabolism ; Cell Line, Tumor ; Epithelial-Mesenchymal Transition/drug effects ; Humans ; Neoplasms/drug therapy ; Neoplasms/metabolism ; Neoplasms/pathology ; Signal Transduction/drug effects ; Signal Transduction/physiology ; Transcription Factors/antagonists & inhibitors ; Transcription Factors/metabolism
Keywords
EMT ;  Epithelial-mesenchymal transition ; Oncogenes ; Snail ;  Therapeutic resistance ; Wnt
Abstract
The epithelial-mesenchymal transition (EMT) comprises an essential biological process involving cancer progression as well as initiation. While the EMT has been regarded as a phenotypic conversion from epithelial to mesenchymal cells, recent evidence indicates that it plays a critical role in stemness, metabolic reprogramming, immune evasion and therapeuticresistance of cancer cells. Interestingly, several transcriptional repressors including Snail (SNAI1), Slug (SNAI2) and the ZEB family constitute key players for EMT in cancer as well as in the developmental process. Note that the dynamic conversion between EMT and epithelialreversion (mesenchymal-epithelial transition, MET) occurs through variable intermediate-hybrid states rather than being a binary process. Given the close connection between oncogenic signaling and EMT repressors, the EMT has emerged as a therapeutic target or goal (in terms of MET reversion) in cancer therapy. Here we review the critical role of EMT in therapeutic resistance and the importance of EMT as a therapeutic target for human cancer.
Full Text
https://link.springer.com/article/10.1007%2Fs12272-018-01108-7
DOI
10.1007/s12272-018-01108-7
Appears in Collections:
5. Research Institutes (연구소) > Oral Cancer Research Institute (구강종양연구소) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Oral Pathology (구강병리학교실) > 1. Journal Papers
Yonsei Authors
Kim, Nam Hee(김남희) ORCID logo https://orcid.org/0000-0002-3087-5276
Yook, Jong In(육종인) ORCID logo https://orcid.org/0000-0002-7318-6112
Cho, Eunae(조은애산드라) ORCID logo https://orcid.org/0000-0002-0820-3019
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/170389
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