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High circulating follistatin-like protein 1 as a biomarker of a metabolically unhealthy state

Authors
 Sun-Young Lee  ;  Deog-Yoon Kim  ;  Mi Kyung Kwak  ;  Seong Hee Ahn  ;  Hyeonmok Kim  ;  Beom-Jun Kim  ;  Jung-Min Koh  ;  Yumie Rhee  ;  Chong Hwa Kim  ;  Ki Hyun Baek  ;  Yong-Ki Min  ;  Seung Hun Lee  ;  Moo-Il Kang 
Citation
 ENDOCRINE JOURNAL, Vol.66(3) : 241-251, 2019 
Journal Title
ENDOCRINE JOURNAL
ISSN
 0918-8959 
Issue Date
2019
Keywords
Follistatin-likeprotein1 ; Metabolic unhealth ; Subclinical atherosclerosis
Abstract
The inflammatory biomarkers that fully characterize themetabolicallyunhealthy(MU)state-which is a risk factor for cardiovascular disease (CVD)-remain unclear. Recent studies suggestfollistatin-likeprotein1(FSTL1) could be used as abiomarkerfor inflammation and CVD, however there is little information on FSTL1 levels in the MUstate. We aimed to evaluate the associations between FSTL1, the presence of MUstateand subclinical coronary atherosclerosis. In a cross-sectional study, we evaluated FSTL1 levels and their relationship with the presence of MUstateand coronary artery plaques in 230 Korean patients. Significant increase in FSTL1 levels was observed in subjects with MUstate(p = 0.020), but not those with obesitystateaccording to body mass index criteria (p = 0.790). After adjusting for confounders, the odd ratio (OR) for the MUstateamong patients in the highest FSTL1 tertile (T3) was higher in comparison with the lowest tertile (T1) (OR = 3.60, 95% confidence interval [95% CI] =1.20-10.83). In a subgroup (n = 66), FSTL1 levels were also marginally higher in patients with plaques (p = 0.098). The OR for plaque presence in patients with T3 was significantly higher in comparison with T1 after adjusting for confounders (OR = 12.51, 95% CI =1.15-135.73). Plasma FSTL1 may be a usefulbiomarkerfor the risk of MUstateand CVD.
Files in This Item:
T201902183.pdf Download
DOI
10.1507/endocrj.EJ18-0352
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Rhee, Yumie(이유미) ORCID logo https://orcid.org/0000-0003-4227-5638
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/170372
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