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Statins reduce relapse rate in Takayasu arteritis

Authors
 Oh Chan Kwon  ;  Ji Seon Oh  ;  Min-Chan Park  ;  Seokchan Hong  ;  Chang-Keun Lee  ;  Bin Yoo  ;  Yong-Gil Kim 
Citation
 INTERNATIONAL JOURNAL OF CARDIOLOGY, Vol.287 : 111-115, 2019 
Journal Title
 INTERNATIONAL JOURNAL OF CARDIOLOGY 
ISSN
 0167-5273 
Issue Date
2019
Keywords
Relapse ;  Statin ;  Takayasu arteritis
Abstract
BACKGROUND: To investigate the effect of statins on relapse of Takayasu arteritis (TAK), which frequently occurs after achievement of remission. METHODS: We conducted a retrospective study on TAK patients with active disease, diagnosed between 2012 and 2017. Relapse was defined as recurrence of active disease after achieving remission. Demographic and clinical parameters of patients who experienced relapse were compared to those who did not. To identify factors associated with relapse, significant factors identified in this comparison were included in a multivariate Cox regression analysis. Inverse probability of treatment weighting (IPTW)-adjusted analysis was used to evaluate the influence of statins on relapse. RESULTS: Of the total 74 TAK patients, 40 (54.1%) patients received statins, whereas 34 (45.9%) patients did not. Relapse was observed in 36 (48.6%) patients of the total 74 TAK patients. Compared with patients who did not experience relapse, patients who experienced relapse were younger (44.5 ± 13.5 years vs 34.1 ± 12.6 years, p = 0.001), had lower prevalence of hypertension (63.2% vs 38.9%, p = 0.037), more commonly had carotidynia (7.9% vs 27.8%, p = 0.025), had higher LDL-cholesterol (84.8 ± 18.8 mg/dl vs 100.5 ± 26.1 mg/dl, p = 0.010), and were less commonly taking statins (71.1% vs 36.1%, p = 0.003). The use of statins was significant in multivariate Cox regression analysis (adjusted hazard ratio 0.260, 95% confidence interval 0.120-0.563, p = 0.001). Furthermore, IPTW-adjusted analysis confirmed that statin use was associated with a lower risk of relapse (IPTW-adjusted hazard ratio 0.153, 95% confidence interval 0.038-0.616, p = 0.008). CONCLUSION: In TAK, statins can be beneficial in reducing relapse rate after achieving remission.
Full Text
https://www.sciencedirect.com/science/article/pii/S0167527319301949
DOI
10.1016/j.ijcard.2019.02.046
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Park, Min Chan(박민찬) ORCID logo https://orcid.org/0000-0003-1189-7637
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/170368
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