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Recent advances in microfluidic platelet function assays: Moving microfluidics into clinical applications

Authors
 Hoyoon Lee  ;  Wonwhi Na  ;  Byoung-Kwon Lee  ;  Chae-Seung Lim  ;  Sehyun Shin 
Citation
 Clinical Hemorheology and Microcirculation, Vol.71(2) : 249-266, 2019 
Journal Title
 Clinical Hemorheology and Microcirculation 
ISSN
 1386-0291 
Issue Date
2019
MeSH
Blood Platelets/physiology ; Hemostasis ; Humans ; Microfluidic Analytical Techniques/methods ; Platelet Aggregation/physiology ; Platelet Function Tests/methods
Keywords
Platelets ; diagnostic ;  function ;  microfluidic ; test
Abstract
The analysis of platelet aggregation and thrombosis kinetics has significantly advanced with progress in microfluidic technology. However, the results of platelet aggregation tests do not fully reflect the observed clinical outcomes. To address the present unmet clinical needs, the basic but essential biology of platelets should be reconsidered in relation to the characteristics of microfluidic systems employed for platelet tests. To this end, the present article provides an overview of commercially available point of care devices and focuses on recent microfluidicstudies, describing their measurement principles. We critically discuss the characteristics of the microfluidics systems used to evaluate the complex processes underlying plateletaggregation, and that are specifically designed to mimic the pathophysiological environment of blood vessels, including hemodynamic factors as well as blood vessel injury. To this end, we summarize unsolved issues related to the application of platelet function tests based on microfluidics. Overall, we confirm that platelet function tests based on microfluidics provide a versatile platform that encompasses a variety of basic research, as well as clinical diagnostic applications.
Full Text
https://content.iospress.com/articles/clinical-hemorheology-and-microcirculation/ch189416
DOI
10.3233/CH-189416
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Lee, Byoung Kwon(이병권) ORCID logo https://orcid.org/0000-0001-9259-2776
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/170289
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