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Critical Role of ATP-P2X7 Axis in UV-Induced Melanogenesis

Authors
 Eun Jung Lee  ;  Ji Young Kim  ;  Yuri Ahn  ;  Byeong-min Lee  ;  Yunkyung Heo  ;  Shinwon Hwang  ;  Si-Hyung Lee  ;  Jinu Lee  ;  Gehoon Chung  ;  Sang Ho Oh 
Citation
 JOURNAL OF INVESTIGATIVE DERMATOLOGY, Vol.139(7) : 1554-1563.e6, 2019 
Journal Title
 JOURNAL OF INVESTIGATIVE DERMATOLOGY 
ISSN
 0022-202X 
Issue Date
2019
Abstract
Purinergic signaling participates in skin physiology and pathology, such as hair growth, wound healing, inflammation, pain, and skin cancer. However, few studies have investigated the involvement of purinergic signaling in skin pigmentation. This study demonstrated that extracellular adenosine 5'-triphosphate (ATP) released from keratinocytes by UVB radiation promotes melanin production in primary human epidermal melanocytes and ex vivo skin cultures. Intracellular calcium ion and protein kinase C/CREB signaling contributed to ATP-mediated melanogenesis. Also, P2X7 receptor was proven to play a pivotal role in ATP-mediated melanogenesis because P2X7 receptor blockade abrogated ATP-induced melanin production. In addition, MNT1 cells with P2X7 receptor knockout using CRISPR/Cas9 system did not show any increase in MITF expression when co-cultured with UV-irradiated keratinocytes compared to MNT1 cells with intact P2X7 receptor, which showed increased expression of MITF. In conclusion, our results indicate that the extracellular ATP-P2X7 signaling axis is an adjunctive mechanism in UV-induced melanogenesis. Furthermore, ATP-induced purinergic signaling in melanocytes may alter skin pigmentation.
Full Text
https://www.sciencedirect.com/science/article/pii/S0022202X19313466
DOI
10.1016/j.jid.2019.02.031
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Dermatology (피부과학교실) > 1. Journal Papers
Yonsei Authors
Oh, Sang Ho(오상호) ORCID logo https://orcid.org/0000-0002-4477-1400
Hwang, Shinwon(황신원) ORCID logo https://orcid.org/0000-0002-0202-7800
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/170259
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