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Two Distinct Subsets Are Identified from the Peritoneal Myeloid Mononuclear Cells Expressing both CD11c and CD115

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dc.contributor.author나혜영-
dc.contributor.author박채규-
dc.contributor.author신성재-
dc.date.accessioned2019-07-23T06:39:06Z-
dc.date.available2019-07-23T06:39:06Z-
dc.date.issued2019-
dc.identifier.issn1598-2629-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/170255-
dc.description.abstractTo this date, the criteria to distinguish peritoneal macrophages and dendritic cells (DCs) are not clear. Here we delineate the subsets of myeloid mononuclear cells in the mouse peritoneal cavity. Considering phenotypical, functional, and ontogenic features, peritoneal myeloidmononuclear cells are divided into 5 subsets: large peritoneal macrophages (LPMs), small peritoneal macrophages (SPMs), DCs, and 2 MHCII+CD11c+CD115+ subpopulations (i.e., MHCII+CD11c+CD115+CD14-CD206- and MHCII+CD11c+CD115+CD14+CD206+). Among them, 2 subsets of competent Ag presenting cells are demonstrated with distinct functional characteristics, one being DCs and the other being MHCII+CD11c+CD115+CD14-CD206- cells. DCs are able to promote fully activated T cells and superior in expanding cytokine producing inflammatory T cells, whereas MHCII+CD11c+CD115+CD14-CD206- cells generate partially activated T cells and possess a greater ability to induce Treg under TGF-β and retinoic acid conditions. While the development of DCs and MHCII+CD11c+CD115+CD14-CD206- cells are responsive to the treatment of FLT3 ligand and GM-CSF, the number of LPMs, SPMs, and MHCII+CD11c+CD115+CD14+CD206+ cells are only influenced by the injection of GM-CSF. In addition, the analysis of gene expression profiles among MHCII+ peritoneal myeloidmononuclear cells reveals that MHCII+CD11c+CD115+CD14+CD206+ cells share high similarity with SPMs, whereas MHCII+CD11c+CD115+CD14-CD206- cells are related to peritoneal DC2s. Collectively, our study identifies 2 distinct subpopulations of MHCII+CD11c+CD115+ cells, 1) MHCII+CD11c+CD115+CD14-CD206- cells closely related to peritoneal DC2s and 2) MHCII+CD11c+CD115+CD14+CD206+ cells to SPMs.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherKorea Society for Immunology : Korean Society of Biological Response Modifiers-
dc.relation.isPartOfIMMUNE NETWORK-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleTwo Distinct Subsets Are Identified from the Peritoneal Myeloid Mononuclear Cells Expressing both CD11c and CD115-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentBioMedical Science Institute (의생명과학부)-
dc.contributor.googleauthorMoah Sohn-
dc.contributor.googleauthorHye Young Na-
dc.contributor.googleauthorSeul Hye Ryu-
dc.contributor.googleauthorWanho Choi-
dc.contributor.googleauthorHyunju In-
dc.contributor.googleauthorHyun Soo Shin-
dc.contributor.googleauthorJi Soo Park-
dc.contributor.googleauthorDahee Shim-
dc.contributor.googleauthorSung Jae Shin-
dc.contributor.googleauthorChae Gyu Park-
dc.identifier.doi10.4110/in.2019.19.e15-
dc.contributor.localIdA04556-
dc.contributor.localIdA01718-
dc.contributor.localIdA01718-
dc.contributor.localIdA02114-
dc.contributor.localIdA02114-
dc.relation.journalcodeJ01033-
dc.identifier.eissn2092-6685-
dc.identifier.pmid31281712-
dc.subject.keywordAntigen presentation-
dc.subject.keywordDendritic cells-
dc.subject.keywordMacrophages-
dc.subject.keyword Peritoneal cavity-
dc.subject.keywordT cells-
dc.contributor.alternativeNameNa, Hye Young-
dc.contributor.affiliatedAuthor나혜영-
dc.contributor.affiliatedAuthor박채규-
dc.contributor.affiliatedAuthor박채규-
dc.contributor.affiliatedAuthor신성재-
dc.contributor.affiliatedAuthor신성재-
dc.citation.volume19-
dc.citation.number3-
dc.citation.startPagee15-
dc.identifier.bibliographicCitationIMMUNE NETWORK, Vol.19(3) : e15, 2019-
Appears in Collections:
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Microbiology (미생물학교실) > 1. Journal Papers

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