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Subcutaneous Immunotherapy in Patients with Fagales Pollen-Induced Oral Allergy Syndrome

Authors
 Nasil Kong  ;  Sunyoung Kim  ;  Sang Chul Lee  ;  Kyung Hee Park  ;  Jae-Hyun Lee  ;  Jung-Won Park 
Citation
 YONSEI MEDICAL JOURNAL, Vol.60(4) : 389-394, 2019 
Journal Title
 YONSEI MEDICAL JOURNAL 
ISSN
 0513-5796 
Issue Date
2019
MeSH
Adolescent ; Adult ; Allergens ; Fagales/chemistry ; Female ; Food Hypersensitivity/therapy ; Humans ; Immunotherapy/methods ; Injections, Subcutaneous ; Male ; Middle Aged ; Plant Extracts/administration & dosage ; Plant Extracts/immunology ; Pollen/immunology ; Republic of Korea ; Surveys and Questionnaires ; Treatment Outcome
Keywords
Fagales pollen ;  Oral allergy syndrome ;  subcutaneous immunotherapy
Abstract
Oral allergy syndrome (OAS) is the most common food allergy-related condition in adults. This study aimed to investigate whether subcutaneous immunotherapy (SCIT) with Fagales pollen-containing extracts can improve the clinical symptoms of OAS in Korea. In total, 56 OAS patients were included: 19 subjects treated with SCIT, which included Fagales pollen extracts, and 37 not treated with immunotherapy(IT). We reviewed the patients' medical records and administered a telephone questionnaire at one point to assess baseline OAS features and changes in the patients' OAS and allergic rhinoconjunctivitis (ARC) symptoms after treatment. Only 12 patients who received SCIT and 15 patients that did not receive SCIT could report on changes in OAS symptoms after treatment because the other patients practiced strict avoidance of their culprit fruits and vegetables, and they could not respond to the status of OAS. SCIT reduced the severity of OAS (p=0.005). Nine of the 12 patients (75%) that received SCIT reported a more than 50% reduction in OAS symptoms. In contrast, only three of the 15 patients (20%) that did not receive IT reported more than a 50% reduction in OAS symptoms. SCIT also reduced the severity of ARC symptoms (p<0.001). The results indicate that SCIT with Fagales pollen-containing extracts is associated with improved OAS symptoms in Korea.
Files in This Item:
T201901934.pdf Download
DOI
10.3349/ymj.2019.60.4.389
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Park, Kyung Hee(박경희) ORCID logo https://orcid.org/0000-0003-3605-5364
Park, Jung Won(박중원) ORCID logo https://orcid.org/0000-0003-0249-8749
Lee, Sang Chul(이상철)
Lee, Jae Hyun(이재현) ORCID logo https://orcid.org/0000-0002-0760-0071
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/170234
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