Cited 7 times in
Serotonin receptor 3B polymorphisms are associated with type 2 diabetes: The Korean Genome and Epidemiology Study
DC Field | Value | Language |
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dc.contributor.author | 권유진 | - |
dc.contributor.author | 박병진 | - |
dc.contributor.author | 정동혁 | - |
dc.date.accessioned | 2019-07-23T06:36:26Z | - |
dc.date.available | 2019-07-23T06:36:26Z | - |
dc.date.issued | 2019 | - |
dc.identifier.issn | 0168-8227 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/170231 | - |
dc.description.abstract | AIMS: Serotonin, or 5-hydroxytryptamine (5-HT), and serotonin receptor (HTR) subtypes contribute to controlling energy homeostasis. We investigated the association of polymorphisms of serotonin related genes with type 2 diabetes in Korean adults using a community-based prospective cohort study. METHODS: A total of 8840 participants (4205 Ansung, 4635 Ansan) from the Korean Genome and Epidemiology Study (KoGES)-Ansan and Ansung were included. The mean follow-up duration was 7.6 years, and the Ansan and Ansung cohorts were treated as independent replicates. Individuals with existing and new-onset type 2 diabetes were identified at baseline and follow-up evaluations, respectively. Logistic regression analysis was used to evaluate the association of 3402 single nucleotide polymorphisms (SNPs) in serotonin related genes with type 2 diabetes after adjusting for baseline age, sex, body mass index, drinking status, and smoking status. RESULTS: The baseline case-control comparison revealed significant association of 26 SNPs in HTR3B and HTR2A with type 2 diabetes. Interestingly, HTR3B SNP rs1176744, which is involved in behavioral disorders, was associated with type 2 diabetes (p-value = 0.0002). Furthermore, HTR3B polymorphisms that significantly associated with type 2 diabetes were located in the 3' downstream region. The new-onset type 2 diabetes case-control study revealed significant association of 3 additional SNPs of the HTR4. CONCLUSIONS: We found that rs1176744 in HTR3B was associated with type 2 diabetes. Additionally, our study suggests that polymorphisms in the downstream region of HTR3B may contribute to the development of type 2 diabetes. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Elsevier Scientific Publishers | - |
dc.relation.isPartOf | DIABETES RESEARCH AND CLINICAL PRACTICE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Serotonin receptor 3B polymorphisms are associated with type 2 diabetes: The Korean Genome and Epidemiology Study | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Family Medicine (가정의학교실) | - |
dc.contributor.googleauthor | Yu-Jin Kwon | - |
dc.contributor.googleauthor | Kyung-Won Hong | - |
dc.contributor.googleauthor | Byung Jin Park | - |
dc.contributor.googleauthor | Dong-Hyuk Jung | - |
dc.identifier.doi | 10.1016/j.diabres.2019.05.032 | - |
dc.contributor.localId | A04882 | - |
dc.contributor.localId | A01477 | - |
dc.contributor.localId | A03595 | - |
dc.relation.journalcode | J00723 | - |
dc.identifier.eissn | 1872-8227 | - |
dc.identifier.pmid | 31152805 | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0168822719304978 | - |
dc.subject.keyword | 5-hydroxytryptaminereceptor3B | - |
dc.subject.keyword | Polymorphism | - |
dc.subject.keyword | Serotonin | - |
dc.subject.keyword | Type2diabetes | - |
dc.contributor.alternativeName | Kwon, Yu-Jin | - |
dc.contributor.affiliatedAuthor | 권유진 | - |
dc.contributor.affiliatedAuthor | 박병진 | - |
dc.contributor.affiliatedAuthor | 정동혁 | - |
dc.citation.volume | 153 | - |
dc.citation.startPage | 76 | - |
dc.citation.endPage | 85 | - |
dc.identifier.bibliographicCitation | DIABETES RESEARCH AND CLINICAL PRACTICE, Vol.153 : 76-85, 2019 | - |
dc.identifier.rimsid | 61779 | - |
dc.type.rims | ART | - |
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