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Systemic immune-inflammation index could estimate the cross-sectional high activity and the poor outcomes in immunosuppressive drug-naïve patients with antineutrophil cytoplasmic antibody-associated vasculitis

DC FieldValueLanguage
dc.contributor.author박용범-
dc.contributor.author송정식-
dc.contributor.author이상원-
dc.contributor.author정승민-
dc.date.accessioned2019-07-23T06:35:37Z-
dc.date.available2019-07-23T06:35:37Z-
dc.date.issued2019-
dc.identifier.issn1320-5358-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/170226-
dc.description.abstractOBJECTIVES: We investigated whether systemic immune-inflammation index (SII) at diagnosis can estimate the cross-sectional high activity and predict the poor outcomes in immunosuppressive drug-naïve patients with antineutrophil cytoplasmic antibody-associated vasculitis (AAV). METHODS: We retrospectively reviewed the medical records of 163 patients with AAV and obtained clinical and laboratory data. We calculated Birmingham vasculitis activity score (BVAS) as well as five-factor score (FFS) (2009) at diagnosis. SII at diagnosis was calculated by the equation of (SII at diagnosis = platelet count × neutrophil count/lymphocyte count at diagnosis). Severe AAV was defined as BVAS at diagnosis ≥16. The odds ratio was assessed using the multivariable logistic regression analysis and cumulative survival rates were compared by the Kaplan-Meier survival analysis. RESULTS: The median age at diagnosis was 58.0 years old and 51 patients were men. The median BVAS was 12.0. Fifty-seven patients had severe AAV. The median SII at diagnosis was 1349.6. In the multivariable analysis, only SII exhibited a significant odds ratio for the cross-sectional severe AAV (P = 0.043). We obtained the cut-off of SII at diagnosis for severe AAV as 1573.56. Patients with SII at diagnosis ≥1573.56 exhibited a significantly high relative risk of the cross-sectional severe AAV compared to those without (relative risk 4.625). Furthermore, patients with SII at diagnosis ≥1573.56 exhibited significantly the lower cumulative relapse free and renal survivals than those without. CONCLUSION: Systemic immune-inflammation index at diagnosis could estimate the cross-section severe AAV and predict the poor outcomes in AAV patients.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherBlackwell Science-
dc.relation.isPartOfNEPHROLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleSystemic immune-inflammation index could estimate the cross-sectional high activity and the poor outcomes in immunosuppressive drug-naïve patients with antineutrophil cytoplasmic antibody-associated vasculitis-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.googleauthorYouhyun Kim-
dc.contributor.googleauthorHyeok Choi-
dc.contributor.googleauthorSeung Min Jung-
dc.contributor.googleauthorJason Jungsik Song-
dc.contributor.googleauthorYong-Beom Park-
dc.contributor.googleauthorSang-Won Lee-
dc.identifier.doi10.1111/nep.13491-
dc.contributor.localIdA01579-
dc.contributor.localIdA02057-
dc.contributor.localIdA02057-
dc.contributor.localIdA02824-
dc.contributor.localIdA02824-
dc.contributor.localIdA05179-
dc.contributor.localIdA05179-
dc.relation.journalcodeJ02315-
dc.identifier.eissn1440-1797-
dc.identifier.pmid30203901-
dc.identifier.urlhttps://onlinelibrary.wiley.com/doi/full/10.1111/nep.13491-
dc.subject.keywordactivity-
dc.subject.keyword antineutrophil cytoplasmic antibody-associated vasculitis-
dc.subject.keyword systemic immune-inflammation index-
dc.contributor.alternativeNamePark, Yong Beom-
dc.contributor.affiliatedAuthor박용범-
dc.contributor.affiliatedAuthor송정식-
dc.contributor.affiliatedAuthor송정식-
dc.contributor.affiliatedAuthor이상원-
dc.contributor.affiliatedAuthor이상원-
dc.contributor.affiliatedAuthor정승민-
dc.contributor.affiliatedAuthor정승민-
dc.citation.volume24-
dc.citation.number7-
dc.citation.startPage711-
dc.citation.endPage717-
dc.identifier.bibliographicCitationNEPHROLOGY, Vol.24(7) : 711-717, 2019-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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