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Biodegradable micro-sized discoidal polymeric particles for lung-targeted delivery system

DC FieldValueLanguage
dc.contributor.author박준영-
dc.contributor.author강원준-
dc.date.accessioned2019-07-18T01:43:33Z-
dc.date.available2019-07-18T01:43:33Z-
dc.date.issued2019-
dc.identifier.issn0142-9612-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/170147-
dc.description.abstractVarious types of particle-based drug delivery systems have been explored for the treatment of pulmonary diseases; however, bio-distribution and elimination of the particles should be monitored for better understanding of their therapeutic efficacy and safety. This study aimed to characterize the biological properties of micro-sized discoidal polymeric particles (DPPs) as lung-targeted drug delivery carriers. DPPs were prepared using a top-down fabrication approach and characterized by assessing size and zeta potential. They were labeled with zirconium-89 (89Zr), and bio-distribution studies and PET imaging were performed for 7 days after intravenous administration. Their hydrodynamic size was 2.8 ± 6.1 μm and average zeta potential was -39.9 ± 5.39 mV. At doses of 5, 12.5, and 25 mg/kg, they showed no acute toxicity in nude mice. Desferrioxamine (DFO)-functionalized 89Zr-labeled DPPs gave a decay-corrected radiochemical yield of 82.1 ± 0.2%. Furthermore, 89Zr-DPPs, from chelate-free labeling methods, showed a yield of 48.5 ± 0.9%. Bio-distribution studies and PET imaging showed 89Zr-DFO-DPPs to be mainly accumulated in the lungs and degraded within 3 d of injection. However, 89Zr-DFO-DPPs showed significantly low uptake in the bone. Overall, our results suggested micro-sized DPPs as promising drug delivery carriers for the targeted treatment of various pulmonary diseases.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherElsevier Science-
dc.relation.isPartOfBIOMATERIALS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleBiodegradable micro-sized discoidal polymeric particles for lung-targeted delivery system-
dc.typeArticle-
dc.contributor.collegeOthers-
dc.contributor.departmentSeverance Hospital (세브란스병원)-
dc.contributor.googleauthorJun Young Park-
dc.contributor.googleauthorSanghyo Park-
dc.contributor.googleauthorTae Sup Lee-
dc.contributor.googleauthorYong Hwa Hwang-
dc.contributor.googleauthorJung Young Kim-
dc.contributor.googleauthorWon Jun Kang-
dc.contributor.googleauthorJaehong Key-
dc.identifier.doi10.1016/j.biomaterials.2019.119331-
dc.contributor.localIdA05200-
dc.contributor.localIdA00062-
dc.contributor.localIdA00062-
dc.relation.journalcodeJ00312-
dc.identifier.eissn1878-5905-
dc.identifier.pmid31299455-
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/S0142961219304302-
dc.contributor.alternativeNamePark, Jun Young-
dc.contributor.affiliatedAuthor박준영-
dc.contributor.affiliatedAuthor강원준-
dc.contributor.affiliatedAuthor강원준-
dc.citation.volume2018-
dc.citation.startPage119331-
dc.identifier.bibliographicCitationBIOMATERIALS, Vol.2018 : 119331, 2019-
Appears in Collections:
7. Others (기타) > Others (기타) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 1. Journal Papers

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