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타우 PET영상을 위한 18F-THK5351의 표지방법 개발

DC FieldValueLanguage
dc.contributor.author박준영-
dc.contributor.author전중현-
dc.date.accessioned2019-07-18T01:43:20Z-
dc.date.available2019-07-18T01:43:20Z-
dc.date.issued2018-
dc.identifier.issn1229-9901-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/170144-
dc.description.abstractPurpose 18F-THK5351 is the newly developed PET probe for tau imaging in alzheimer's disease. The purpose of study was to establish the automated production of 18F-THK5351 on a commercial module. Materials and Methods Two different approaches were evaluated for the synthesis of 18F-THK5351. The first approach (method I) included the nucleophilic $^{18}F$ -fluorination of the tosylate precursor, subsequently followed by pre-HPLC purification of crude reaction mixture with SPE cartridge. In the second approach (method II), the crude reaction mixture was directly introduced to a semi-preparative HPLC without SPE purification. The radiosynthesis of 18F-THK5351 was performed on a commercial GE $TRACERlab^{TM}$ $FX-_{FN}$ module. Quality control of 18F-THK5351 was carried out to meet the criteria guidelined in USP for PET radiopharmaceuticals. Results The overall radiochemical yield of method I was $23.8{\pm}1.9%$ (n=4) as the decay-corrected yield (end of synthesis, EOS) and the total synthesis time was $75{\pm}3min$ . The radiochemical yield of method II was $31.9{\pm}6.7%$ (decay-corrected, n=10) and the total preparation time was $70{\pm}2min$ . The radiochemical purity was>98%. Conclusion This study shows that method II provides higher radiochemical yield and shorter production time compared to the pre-SPE purification described in method I. The 18F-THK5351 synthesis by method II will be ideal for routine clinical application, considering short physical half-life of fluorine-18 ($t_{1/2}=110min$ ).-
dc.description.statementOfResponsibilityopen-
dc.languageKorean-
dc.publisher대한핵의학기술학회-
dc.relation.isPartOfKorean Journal of Nuclear Medicine Technology (핵의학기술)-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.title타우 PET영상을 위한 18F-THK5351의 표지방법 개발-
dc.title.alternativeDevelopment of Radiosynthetic Methods of 18F-THK5351 for tau PET Imaging-
dc.typeArticle-
dc.contributor.collegeOthers-
dc.contributor.departmentSeverance Hospital (세브란스병원)-
dc.contributor.googleauthor박준영-
dc.contributor.googleauthor손정민-
dc.contributor.googleauthor전중현-
dc.contributor.localIdA05200-
dc.contributor.localIdA05406-
dc.contributor.localIdA05406-
dc.relation.journalcodeJ03625-
dc.subject.keywordAlzheimer’s Disease-
dc.subject.keyword18F-THK5351-
dc.subject.keywordtau PET-
dc.subject.keywordRadiopharmaceutical-
dc.contributor.alternativeNamePark, Jun Young-
dc.contributor.affiliatedAuthor박준영-
dc.contributor.affiliatedAuthor전중현-
dc.contributor.affiliatedAuthor전중현-
dc.citation.volume22-
dc.citation.number1-
dc.citation.startPage51-
dc.citation.endPage54-
dc.identifier.bibliographicCitationKorean Journal of Nuclear Medicine Technology (핵의학기술), Vol.22(1) : 51-54, 2018-
Appears in Collections:
7. Others (기타) > Gangnam Severance Hospital (강남세브란스병원) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 1. Journal Papers

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