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An optimized radiosynthesis of 18F-THK-5351 for routine production on TRACERlab™ FXFN
DC Field | Value | Language |
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dc.contributor.author | 박준영 | - |
dc.contributor.author | 전중현 | - |
dc.contributor.author | 윤미진 | - |
dc.date.accessioned | 2019-07-18T01:43:13Z | - |
dc.date.available | 2019-07-18T01:43:13Z | - |
dc.date.issued | 2017 | - |
dc.identifier.issn | 2384-1583 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/170143 | - |
dc.description.abstract | 18F−THK−5351 18F−THK−5351 is a PET radiotracer to image the hyperphosphorylated tau fibrillar aggregates in human brain. This protocol describes the optimized radiosynthesis of 18F−THK−5351 18F−THK−5351 using a commercial GE TRACERlabTM TRACERlabTM FXFN FXFN radiosynthesis module. 18F−THK−5351 18F−THK−5351 was prepared by nucleophilic [18F 18F ]fluorination from its protected tosylate precursors, (S)-(2-(2-methylaminopyrid-5-yl)-6-[[2-(tetrahydro-2H-pyran-2-yloxy)-3-tosyloxy]propoxy] quinolone(THK-5352), at 110∘C 110∘C for 10 min in dimethyl sulfoxide, followed by deprotection with 1 N HCl. The average radiochemical yield of 18F−THK−5351 18F−THK−5351 was 31.9±6.7 31.9±6.7 (decay-corrected, n = 10), with molar activity of 198.1±33.9GBq/μmol 198.1±33.9GBq/μmol (5.4±0.9Ci/μmol 5.4±0.9Ci/μmol , n = 10). The radiochemical purity was determined to be above 98%. The overall production time including HPLC purification is approximately 70 min. This fully-automated protocol is validated for clinical use. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | Korean | - |
dc.publisher | 대한방사선의약품학회 | - |
dc.relation.isPartOf | Journal of Radiopharmaceuticals and Molecular Probes (대한방사성의약품학회지) | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | An optimized radiosynthesis of 18F-THK-5351 for routine production on TRACERlab™ FXFN | - |
dc.type | Article | - |
dc.contributor.college | Others | - |
dc.contributor.department | Severance Hospital (세브란스병원) | - |
dc.contributor.googleauthor | Jun Young Park | - |
dc.contributor.googleauthor | Jeongmin Son | - |
dc.contributor.googleauthor | Mijin Yun | - |
dc.contributor.googleauthor | Joong-Hyun Chun | - |
dc.contributor.localId | A05200 | - |
dc.contributor.localId | A05406 | - |
dc.contributor.localId | A02550 | - |
dc.relation.journalcode | J03624 | - |
dc.identifier.eissn | 2508-3848 | - |
dc.subject.keyword | 18F−THK−5351 | - |
dc.subject.keyword | Tau imaging | - |
dc.subject.keyword | Fluorine-18 | - |
dc.subject.keyword | PET | - |
dc.subject.keyword | Radiotracer | - |
dc.subject.keyword | Automation | - |
dc.contributor.alternativeName | Park, Jun Young | - |
dc.contributor.affiliatedAuthor | 박준영 | - |
dc.contributor.affiliatedAuthor | 전중현 | - |
dc.contributor.affiliatedAuthor | 윤미진 | - |
dc.citation.volume | 3 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 91 | - |
dc.citation.endPage | 97 | - |
dc.identifier.bibliographicCitation | Journal of Radiopharmaceuticals and Molecular Probes (대한방사성의약품학회지), Vol.3(2) : 91-97, 2017 | - |
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