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An optimized radiosynthesis of 18F-THK-5351 for routine production on TRACERlab™ FXFN

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dc.contributor.author박준영-
dc.contributor.author전중현-
dc.contributor.author윤미진-
dc.date.accessioned2019-07-18T01:43:13Z-
dc.date.available2019-07-18T01:43:13Z-
dc.date.issued2017-
dc.identifier.issn2384-1583-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/170143-
dc.description.abstract18F−THK−5351 18F−THK−5351 is a PET radiotracer to image the hyperphosphorylated tau fibrillar aggregates in human brain. This protocol describes the optimized radiosynthesis of 18F−THK−5351 18F−THK−5351 using a commercial GE TRACERlabTM TRACERlabTM FXFN FXFN radiosynthesis module. 18F−THK−5351 18F−THK−5351 was prepared by nucleophilic [18F 18F ]fluorination from its protected tosylate precursors, (S)-(2-(2-methylaminopyrid-5-yl)-6-[[2-(tetrahydro-2H-pyran-2-yloxy)-3-tosyloxy]propoxy] quinolone(THK-5352), at 110∘C 110∘C for 10 min in dimethyl sulfoxide, followed by deprotection with 1 N HCl. The average radiochemical yield of 18F−THK−5351 18F−THK−5351 was 31.9±6.7 31.9±6.7 (decay-corrected, n = 10), with molar activity of 198.1±33.9GBq/μmol 198.1±33.9GBq/μmol (5.4±0.9Ci/μmol 5.4±0.9Ci/μmol , n = 10). The radiochemical purity was determined to be above 98%. The overall production time including HPLC purification is approximately 70 min. This fully-automated protocol is validated for clinical use.-
dc.description.statementOfResponsibilityopen-
dc.languageKorean-
dc.publisher대한방사선의약품학회-
dc.relation.isPartOfJournal of Radiopharmaceuticals and Molecular Probes (대한방사성의약품학회지)-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleAn optimized radiosynthesis of 18F-THK-5351 for routine production on TRACERlab™ FXFN-
dc.typeArticle-
dc.contributor.collegeOthers-
dc.contributor.departmentSeverance Hospital (세브란스병원)-
dc.contributor.googleauthorJun Young Park-
dc.contributor.googleauthorJeongmin Son-
dc.contributor.googleauthorMijin Yun-
dc.contributor.googleauthorJoong-Hyun Chun-
dc.contributor.localIdA05200-
dc.contributor.localIdA05406-
dc.contributor.localIdA02550-
dc.relation.journalcodeJ03624-
dc.identifier.eissn2508-3848-
dc.subject.keyword18F−THK−5351-
dc.subject.keywordTau imaging-
dc.subject.keywordFluorine-18-
dc.subject.keywordPET-
dc.subject.keywordRadiotracer-
dc.subject.keywordAutomation-
dc.contributor.alternativeNamePark, Jun Young-
dc.contributor.affiliatedAuthor박준영-
dc.contributor.affiliatedAuthor전중현-
dc.contributor.affiliatedAuthor윤미진-
dc.citation.volume3-
dc.citation.number2-
dc.citation.startPage91-
dc.citation.endPage97-
dc.identifier.bibliographicCitationJournal of Radiopharmaceuticals and Molecular Probes (대한방사성의약품학회지), Vol.3(2) : 91-97, 2017-
Appears in Collections:
6. Others (기타) > Severance Hospital (세브란스병원) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 1. Journal Papers

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