Cited 7 times in
A comparative study of 188Re(V)-meso-DMSA and 188Re(V)-rac-DMSA: preparation and in vivo evaluation in nude mice xenografted with a neuroendocrine tumor
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 박준영 | - |
dc.date.accessioned | 2019-07-18T01:43:02Z | - |
dc.date.available | 2019-07-18T01:43:02Z | - |
dc.date.issued | 2007 | - |
dc.identifier.issn | 0969-8051 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/170141 | - |
dc.description.abstract | Dimercaptosuccinic acid (DMSA) exists in meso and racemic (rac) forms. Unlike a meso isomer, rac-2,3-DMSA is very soluble in water, strongly acidic solutions and organic solvents. Despite these differences, rac-2,3-DMSA has not been studied as a radiopharmaceutical. In this study, (188)Re complexes with diastereomeric DMSA were prepared to compare the properties of 188Re(V)-rac-DMSA with those of 188Re(V)-meso-DMSA in in vitro and in vivo models. METHODS: rac-2,3-DMSA was synthesized and radiolabeled with 188Re. The biodistribution and gamma camera imaging of 188Re(V)-meso-DMSA and 188Re(V)-rac-DMSA were performed in nude mice subcutaneously implanted with PC-12 cell lines. RESULTS AND CONCLUSIONS: Both 188Re(V)-meso-DMSA and 188Re(V)-rac-DMSA showed excellent radiochemical purity and stability at room temperature. Compared with 188Re(V)-meso-DMSA, 188Re(V)-rac-DMSA needed a higher concentration of rac-DMSA and metabisulfite for maximum yields. 188Re(V)-meso-DMSA showed high labeling efficiency at pH 2, whereas 188Re(V)-rac-DMSA showed maximum yields at pH 5. The tumor uptake of 188Re(V)-rac-DMSA was 3.5 times higher than that of 188Re(V)-meso-DMSA at 1 h (P<.01). Gamma camera images showed that 188Re(V)-rac-DMSA was more selectively localized than 188Re(V)-meso-DMSA at the tumor region in a xenograft model. These results demonstrate that 188Re(V)-rac-DMSA may have better potential than 188Re(V)-meso-DMSA as a therapeutic agent against neuroendocrine tumors. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Elsevier | - |
dc.relation.isPartOf | NUCLEAR MEDICINE AND BIOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Cell Line | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Isotope Labeling | - |
dc.subject.MESH | Metabolic Clearance Rate | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Mice, Inbred C57BL | - |
dc.subject.MESH | Mice, Nude | - |
dc.subject.MESH | Organ Specificity | - |
dc.subject.MESH | Organometallic Compounds/pharmacokinetics* | - |
dc.subject.MESH | Organometallic Compounds/therapeutic use | - |
dc.subject.MESH | Pheochromocytoma/diagnostic imaging | - |
dc.subject.MESH | Pheochromocytoma/metabolism* | - |
dc.subject.MESH | Pheochromocytoma/radiotherapy | - |
dc.subject.MESH | Radionuclide Imaging | - |
dc.subject.MESH | Radiopharmaceuticals/chemical synthesis | - |
dc.subject.MESH | Radiopharmaceuticals/pharmacokinetics | - |
dc.subject.MESH | Radiopharmaceuticals/therapeutic use | - |
dc.subject.MESH | Rats | - |
dc.subject.MESH | Succimer/pharmacokinetics* | - |
dc.subject.MESH | Succimer/therapeutic use | - |
dc.subject.MESH | Tissue Distribution | - |
dc.title | A comparative study of 188Re(V)-meso-DMSA and 188Re(V)-rac-DMSA: preparation and in vivo evaluation in nude mice xenografted with a neuroendocrine tumor | - |
dc.type | Article | - |
dc.contributor.college | Others | - |
dc.contributor.department | Severance Hospital (세브란스병원) | - |
dc.contributor.googleauthor | Jun-Young Park | - |
dc.contributor.googleauthor | Tae-Sup Lee | - |
dc.contributor.googleauthor | Tae-Hyun Choi | - |
dc.contributor.googleauthor | Gi-Jeong Cheon | - |
dc.contributor.googleauthor | Chang-Woon Choi | - |
dc.contributor.googleauthor | Ok-Doo Awh | - |
dc.identifier.doi | 10.1016/j.nucmedbio.2007.06.016 | - |
dc.contributor.localId | A05200 | - |
dc.relation.journalcode | J02381 | - |
dc.identifier.eissn | 1872-9614 | - |
dc.identifier.pmid | 17998108 | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0969805107001783 | - |
dc.contributor.alternativeName | Park, Jun Young | - |
dc.contributor.affiliatedAuthor | 박준영 | - |
dc.citation.volume | 34 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | 1029 | - |
dc.citation.endPage | 1036 | - |
dc.identifier.bibliographicCitation | NUCLEAR MEDICINE AND BIOLOGY, Vol.34(8) : 1029-1036, 2007 | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.