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Pharmacologic targeting of β-catenin improves fracture healing in old mice

Authors
 Yoon Hae Kwak  ;  Tomasa Barrientos  ;  Bridgette Furman  ;  Hazel Zhang  ;  Vijitha Puviindran  ;  Hattie Cutcliffe  ;  Jonas Herfarth  ;  Eugene Nwankwo  ;  Benjamin A. Alman 
Citation
 Scientific Reports, Vol.9(1) : 9005, 2019 
Journal Title
 Scientific Reports 
Issue Date
2019
Abstract
β-catenin protein needs to be precisely regulated for effective fracture repair. The pace of fracture healing slows with age, associated with a transient increase in β-catenin during the initial phase of the repair process. Here we examined the ability of pharmacologic agents that target β-catenin to improve the quality of fracture repair in old mice. 20 month old mice were treated with Nefopam or the tankyrase inhibitor XAV939 after a tibia fracture. Fractures were examined 21 days later by micro-CT and histology, and 28 days later using mechanical testing. Daily treatment with Nefopam for three or seven days but not ten days improved the amount of bone present at the fracture site, inhibited β-catenin protein level, and increased colony forming units osteoblastic from bone marrow cells. At 28 days, treatment increased the work to fracture of the injured tibia. XAV939 had a more modest effect on β-catenin protein, colony forming units osteoblastic, and the amount of bone at the fracture site. This data supports the notion that high levels of β-catenin in the early phase of fracture healing in old animals slows osteogenesis, and suggests a pharmacologic approach that targets β-catenin to improve fracture repair in the elderly.
Files in This Item:
T201902002.pdf Download
DOI
10.1038/s41598-019-45339-0
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Orthopedic Surgery (정형외과학교실) > 1. Journal Papers
Yonsei Authors
Kwak, Yoon Hae(곽윤해) ORCID logo https://orcid.org/0000-0002-0596-1228
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/170101
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