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Development and Validation of Ovarian Symptom Index-18 and Neurotoxicity-4 for Korean Patients with Ovarian, Fallopian Tube, or Primary Peritoneal Cancer

Authors
 Maria Lee  ;  Yumi Lee  ;  Kidong Kim  ;  Eun Young Park  ;  Myong Cheol Lim  ;  Jung-Sup Kim  ;  Hee Seung Kim  ;  Yong-Beom Kim  ;  Yong-Man Kim  ;  Jungnam Joo  ;  Sang Yoon Park  ;  Chel Hun Choi  ;  Jae-Hoon Kim 
Citation
 CANCER RESEARCH AND TREATMENT, Vol.51(1) : 112-118, 2019 
Journal Title
 CANCER RESEARCH AND TREATMENT 
ISSN
 1598-2998 
Issue Date
2019
MeSH
Adult ; Aged ; Fallopian Tube Neoplasms/drug therapy ; Fallopian Tube Neoplasms/psychology* ; Female ; Humans ; Middle Aged ; Ovarian Neoplasms/drug therapy ; Ovarian Neoplasms/psychology* ; Peritoneal Neoplasms/drug therapy ; Peritoneal Neoplasms/psychology* ; Quality of Life/psychology ; Reproducibility of Results ; Republic of Korea ; Surveys and Questionnaires ; Translations
Keywords
Ovarian neoplasm ; Questionnaires ; Surveys
Abstract
PURPOSE: The purpose of this study was to develop Korean versions of the National Comprehensive Cancer Network/Functional Assessment of Cancer Therapy (NCCN-FACT) Ovarian Symptom Index-18 (NFOSI-18) and FACT/Gynecologic Oncology Group (FACT-GOG) Neurotoxicity 4-item (NTX-4), evaluating their reliability and reproducibility. Materials and Methods: In converting NFOSI-18 and NTX-4, the following steps were performed: forward translation, backward translation, expert review, pretest of preliminary format, and finalization of Korean versions (K-NFOSI-18 and K-NTX-4). Patients were enrolled from six institutions where each had completed chemotherapy for ovarian, tubal, or peritoneal cancer at least 1 month earlier. In addition to demographics obtained by questionnaire, all subjects were assessed via K-NFOSI-18, K-NTX-4, and a Korean version of the EuroQoL-5 Dimension. Internal structural validity and reliability were evaluated using item internal consistency, item discriminant validity, and Cronbach's α. To evaluate test-retest reliability, K-NFOSI-18 and K-NTX-4 were readministered after 7-21 days, and intraclass correlation coefficients (ICCs) were calculated. RESULTS: Of the 250 women enrolled during the 3-month recruitment period, 13 withdrew or did not respond, leaving 237 (94.8%) for the analyses. Mean patient age was 54.3±10.8 years. Re-testing was performed in 190 patients (80.2%). The total K-NFOSI-18 and K-NTX-4 scores were 49 (range, 20 to 72) and 9 (range, 0 to 16), respectively, with high reliability (Cronbach's α=0.84 and 0.89, respectively) and reproducibility (ICC=0.77 and 0.84, respectively) achieved in retesting. CONCLUSION: Both NFOSI-18 and NTX-4 were successfully developed in Korean with minimal modification. Each Korean version showed high internal consistency and reproducibility.
Files in This Item:
T201901768.pdf Download
DOI
10.4143/crt.2017.361
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Obstetrics and Gynecology (산부인과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Jae Hoon(김재훈) ORCID logo https://orcid.org/0000-0001-6599-7065
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/170071
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