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Allogeneic keratinocyte for intractable chronic diabetic foot ulcers: A prospective observational study

Authors
 Yeok G. Hwang  ;  Jin W. Lee  ;  Kwang H. Park  ;  Seung H. Han 
Citation
 INTERNATIONAL WOUND JOURNAL, Vol.16(2) : 486-491, 2019 
Journal Title
 INTERNATIONAL WOUND JOURNAL 
ISSN
 1742-4801 
Issue Date
2019
Keywords
diabetic foot ulcer ; keratinocytes ; treatment outcome ; wound healing
Abstract
Chronic diabetic foot ulcers (DFUs) are a common problem in patients with diabetes and are often difficult to treat. The application of newly developed dressing material in patients with chronic DFUs has been reported to be effective. The purpose of this study was to evaluate the usefulness of allogeneic keratinocyte treatment for chronic DFUs. We performed weekly allogeneic keratinocyte treatment for up to 12 weeks in 71 patients with intractable DFUs. We investigated healing rate, wound-healing velocity, and time to 50% wound size reduction and analysed factors affecting ulcer healing. Fifty-six patients (78.8%) had complete wound healing. Forty-six patients (64.7%) showed complete healing within an average of 6.1 weeks, and 10 patients (14.1%) showed partial healing with an average 35.5% reduction vs initial size at the end of follow up. The 10 patients who showed partial healing continued to receive treatment after the 12-week study period. The mean time to complete wound healing was 7.8 weeks. Fifteen patients (21.1%) experienced treatment failure because of infection, local necrosis, no change in ulcer size, or osteomyelitis during the follow-up period. No adverse events were observed. Allogeneic keratinocyte treatment is effective for chronic, difficult-to-treat DFUs.
Full Text
https://onlinelibrary.wiley.com/doi/full/10.1111/iwj.13061
DOI
10.1111/iwj.13061
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Orthopedic Surgery (정형외과학교실) > 1. Journal Papers
Yonsei Authors
Park, Kwang Hwan(박광환) ORCID logo https://orcid.org/0000-0002-2110-0559
Lee, Jin Woo(이진우) ORCID logo https://orcid.org/0000-0002-0293-9017
Han, Seung Hwan(한승환) ORCID logo https://orcid.org/0000-0002-7975-6067
Hwang, Yeokgu(황역구)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/170070
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