Cited 17 times in
Association of human antigen class I genes with cold medicine-related Stevens-Johnson syndrome with severe ocular complications in a Korean population
DC Field | Value | Language |
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dc.contributor.author | 서경률 | - |
dc.contributor.author | 전익현 | - |
dc.date.accessioned | 2019-07-11T03:37:33Z | - |
dc.date.available | 2019-07-11T03:37:33Z | - |
dc.date.issued | 2019 | - |
dc.identifier.issn | 0007-1161 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/170064 | - |
dc.description.abstract | BACKGROUND/AIMS: Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are a spectrum of diseases that cause an acute vesiculobullous reaction in the skin and mucous membranes. The occurrence of these diseases is associated with various drugs, a large proportion of which is comprised cold medicines (CM). We try to investigate the association between human leucocyte antigen (HLA) class I genes and CM-related SJS/TEN (CM-SJS/TEN) with severe ocular complications (SOC) in the Korean population. METHODS: This multicentre case-control study enrolled 40 Korean patients with CM-SJS/TEN with SOC and 120 age-matched and sex-matched Korean healthy volunteers between January 2012 and May 2014. HLA genotyping was performed using PCR followed by hybridisation with sequence-specific oligonucleotide probes. RESULTS : The carrier frequency and gene frequency of HLA-A*02:06 were 37.5 % and 20.0 %, respectively, in patients, and 16.7 % and 9.6 %, respectively, in controls (p=0.018). The carrier frequency of HLA-C*03:04 was 30 % in patients and 10.8 % in controls, and gene frequency of HLA-C*03:04 was 15 % in patients and 5.4 % in controls (p=0.003). The carrier frequency and gene frequency of HLA-C*03:03 were 2.5 % and 1.3 %, respectively, in patients, and 20 % and 10.4 %, respectively, in controls (p=0.006). CONCLUSIONS : As per our results, we suggest that HLA-A*02:06 and HLA-C*03:04 might be positive markers for CM-SJS/TEN with SOC, and HLA-C*03:03 might be an indicator of protection against CM-SJS/TEN with SOC in the Korean population. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | BMJ Pub. Group | - |
dc.relation.isPartOf | BRITISH JOURNAL OF OPHTHALMOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Association of human antigen class I genes with cold medicine-related Stevens-Johnson syndrome with severe ocular complications in a Korean population | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Ophthalmology (안과학교실) | - |
dc.contributor.googleauthor | Ikhyun Jun | - |
dc.contributor.googleauthor | John Hoon Rim | - |
dc.contributor.googleauthor | Mee Kum Kim | - |
dc.contributor.googleauthor | Kyung-Chul Yoon | - |
dc.contributor.googleauthor | Choun-Ki Joo | - |
dc.contributor.googleauthor | Shigeru Kinoshita | - |
dc.contributor.googleauthor | Kyoung Yul Seo | - |
dc.contributor.googleauthor | Mayumi Ueta | - |
dc.identifier.doi | 10.1136/bjophthalmol-2018-313263 | - |
dc.contributor.localId | A01870 | - |
dc.contributor.localId | A03541 | - |
dc.relation.journalcode | J00412 | - |
dc.identifier.eissn | 1468-2079 | - |
dc.identifier.pmid | 30705045 | - |
dc.identifier.url | https://bjo.bmj.com/content/103/4/573.long | - |
dc.subject.keyword | experimental laboratory | - |
dc.subject.keyword | genetics | - |
dc.subject.keyword | ocular surface | - |
dc.contributor.alternativeName | Seo, Kyuong Yul | - |
dc.contributor.affiliatedAuthor | 서경률 | - |
dc.contributor.affiliatedAuthor | 전익현 | - |
dc.citation.volume | 103 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 573 | - |
dc.citation.endPage | 576 | - |
dc.identifier.bibliographicCitation | BRITISH JOURNAL OF OPHTHALMOLOGY, Vol.103(4) : 573-576, 2019 | - |
dc.identifier.rimsid | 62245 | - |
dc.type.rims | ART | - |
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