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Association of human antigen class I genes with cold medicine-related Stevens-Johnson syndrome with severe ocular complications in a Korean population

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dc.contributor.author서경률-
dc.contributor.author전익현-
dc.date.accessioned2019-07-11T03:37:33Z-
dc.date.available2019-07-11T03:37:33Z-
dc.date.issued2019-
dc.identifier.issn0007-1161-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/170064-
dc.description.abstractBACKGROUND/AIMS: Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are a spectrum of diseases that cause an acute vesiculobullous reaction in the skin and mucous membranes. The occurrence of these diseases is associated with various drugs, a large proportion of which is comprised cold medicines (CM). We try to investigate the association between human leucocyte antigen (HLA) class I genes and CM-related SJS/TEN (CM-SJS/TEN) with severe ocular complications (SOC) in the Korean population. METHODS: This multicentre case-control study enrolled 40 Korean patients with CM-SJS/TEN with SOC and 120 age-matched and sex-matched Korean healthy volunteers between January 2012 and May 2014. HLA genotyping was performed using PCR followed by hybridisation with sequence-specific oligonucleotide probes. RESULTS : The carrier frequency and gene frequency of HLA-A*02:06 were 37.5 % and 20.0 %, respectively, in patients, and 16.7 % and 9.6 %, respectively, in controls (p=0.018). The carrier frequency of HLA-C*03:04 was 30 % in patients and 10.8 % in controls, and gene frequency of HLA-C*03:04 was 15 % in patients and 5.4 % in controls (p=0.003). The carrier frequency and gene frequency of HLA-C*03:03 were 2.5 % and 1.3 %, respectively, in patients, and 20 % and 10.4 %, respectively, in controls (p=0.006). CONCLUSIONS : As per our results, we suggest that HLA-A*02:06 and HLA-C*03:04 might be positive markers for CM-SJS/TEN with SOC, and HLA-C*03:03 might be an indicator of protection against CM-SJS/TEN with SOC in the Korean population.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherBMJ Pub. Group-
dc.relation.isPartOfBRITISH JOURNAL OF OPHTHALMOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleAssociation of human antigen class I genes with cold medicine-related Stevens-Johnson syndrome with severe ocular complications in a Korean population-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Ophthalmology (안과학교실)-
dc.contributor.googleauthorIkhyun Jun-
dc.contributor.googleauthorJohn Hoon Rim-
dc.contributor.googleauthorMee Kum Kim-
dc.contributor.googleauthorKyung-Chul Yoon-
dc.contributor.googleauthorChoun-Ki Joo-
dc.contributor.googleauthorShigeru Kinoshita-
dc.contributor.googleauthorKyoung Yul Seo-
dc.contributor.googleauthorMayumi Ueta-
dc.identifier.doi10.1136/bjophthalmol-2018-313263-
dc.contributor.localIdA01870-
dc.contributor.localIdA03541-
dc.relation.journalcodeJ00412-
dc.identifier.eissn1468-2079-
dc.identifier.pmid30705045-
dc.identifier.urlhttps://bjo.bmj.com/content/103/4/573.long-
dc.subject.keywordexperimental laboratory-
dc.subject.keywordgenetics-
dc.subject.keywordocular surface-
dc.contributor.alternativeNameSeo, Kyuong Yul-
dc.contributor.affiliatedAuthor서경률-
dc.contributor.affiliatedAuthor전익현-
dc.citation.volume103-
dc.citation.number4-
dc.citation.startPage573-
dc.citation.endPage576-
dc.identifier.bibliographicCitationBRITISH JOURNAL OF OPHTHALMOLOGY, Vol.103(4) : 573-576, 2019-
dc.identifier.rimsid62245-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers

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