Cited 2 times in
Intravitreal dexamethasone implant for central retinal vein occlusion without macular edema
DC Field | Value | Language |
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dc.contributor.author | 강현구 | - |
dc.contributor.author | 김민 | - |
dc.contributor.author | 이성철 | - |
dc.contributor.author | 최은영 | - |
dc.date.accessioned | 2019-07-11T03:37:20Z | - |
dc.date.available | 2019-07-11T03:37:20Z | - |
dc.date.issued | 2019 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/170062 | - |
dc.description.abstract | BACKGROUND: To evaluate the efficacy of an intravitreal dexamethasone (IVD) implant (Ozurdex®) for the treatment of central retinal vein occlusion (CRVO) without macular edema (ME). METHODS: A retrospective cohort study was designed, and 20 eyes of 20 patients diagnosed with non-ischemic CRVO without ME were included. A total of 10 CRVO eyes were observed without treatment, and another 10 CRVO eyes received a single IVD injection at baseline. Mean changes in pathomorphologic parameters of fundus and optical coherence tomography parameters were measured at baseline and at 1, 3, 6, and 12 months. RESULTS: The decreases in venous tortuosity (p = 0.014 for superior; 0.036 for inferior arcades) and width (p = 0.024 for superior; 0.003 for inferior arcades) from baseline to 12 months after injection were significantly greater in the treated group than the observed group. The improvements in RNFL swelling (p = 0.010) and retinal hemorrhage (p = 0.006) were also significantly greater in the treated group. Visual symptom improvement was significantly faster in the treated group (p = 0.001). In two cases, IVD injection resulted in complete resolution of cilioretinal artery occlusion associated with the CRVO, leading to complete visual recovery in 1 week. None of the treated eyes showed signs of ME development, ischemia progression, or neovascularization. CONCLUSIONS: IVD implant was significantly effective in improving venous engorgement, retinal hemorrhage, RNFL swelling, and visual symptoms by presumed alleviation of disc swelling and venous outflow. This treatment may be a considerable treatment option in CRVO patients with no ME. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | BioMed Central | - |
dc.relation.isPartOf | BMC OPHTHALMOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Intravitreal dexamethasone implant for central retinal vein occlusion without macular edema | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Ophthalmology (안과학교실) | - |
dc.contributor.googleauthor | Eun Young Choi | - |
dc.contributor.googleauthor | Hyun Goo Kang | - |
dc.contributor.googleauthor | Sung Chul Lee | - |
dc.contributor.googleauthor | Min Kim | - |
dc.identifier.doi | 10.1186/s12886-019-1097-y | - |
dc.contributor.localId | A04873 | - |
dc.contributor.localId | A00455 | - |
dc.contributor.localId | A02873 | - |
dc.contributor.localId | A05056 | - |
dc.relation.journalcode | J00370 | - |
dc.identifier.eissn | 1471-2415 | - |
dc.identifier.pmid | 30999889 | - |
dc.subject.keyword | Central retinal vein occlusion | - |
dc.subject.keyword | Fundus pathomorphology | - |
dc.subject.keyword | Intravitreal dexamethasone implant | - |
dc.subject.keyword | Ozurdex | - |
dc.subject.keyword | Steroid | - |
dc.contributor.alternativeName | Kang, Hyun Goo | - |
dc.contributor.affiliatedAuthor | 강현구 | - |
dc.contributor.affiliatedAuthor | 김민 | - |
dc.contributor.affiliatedAuthor | 이성철 | - |
dc.contributor.affiliatedAuthor | 최은영 | - |
dc.citation.volume | 19 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 92 | - |
dc.identifier.bibliographicCitation | BMC OPHTHALMOLOGY, Vol.19(1) : 92, 2019 | - |
dc.identifier.rimsid | 62187 | - |
dc.type.rims | ART | - |
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