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Association between nonalbumin proteinuria and renal tubular damage of N-acetyl-β-d-glucosaminidase and its clinical relevance in patients with type 2 diabetes without albuminuria

Authors
 Eugene Han  ;  Mi-Kyung Kim  ;  Yong-ho Lee  ;  Hye Soon Kim  ;  Byung-Wan Lee 
Citation
 JOURNAL OF DIABETES AND ITS COMPLICATIONS, Vol.33(3) : 255-260, 2019 
Journal Title
 JOURNAL OF DIABETES AND ITS COMPLICATIONS 
ISSN
 1056-8727 
Issue Date
2019
Keywords
Albuminuria ; Diabetic kidney disease ; Proteinuria ; Type 2 diabetes ; Urinary N-acetyl-β-d-glucosaminidase ; Urinary nonalbumin proteinuria
Abstract
AIM: Although albuminuria and urinary N-acetyl-β-d-glucosaminidase (uNAG) are known as progression markers of diabetic kidney disease, there is limited information regarding the association between urinary nonalbumin proteinuria (NAP) and uNAG and the clinical relevance thereof in patients without albuminuria. METHODS: This cross-sectional study included samples from 244 consecutive patients with type 2 diabetes mellitus (T2D) without albuminuria. Proteinuria and albuminuria were defined according to protein-to-creatinine ratio (uPCR) and albumin-to-creatinine ratio (uACR), respectively. NAP was indirectly calculated by the difference between uPCR and uACR. RESULTS: NAP and uNAG excretion were significantly correlated (r = 0.525, P < 0.001). Individuals whose NAP levels were in the highest tertile had a longer duration of diabetes, uncontrolled hyperglycemia, and impaired insulin stimulation (all P < 0.05), although more patients in the highest NAP tertile were prescribed insulin and sulfonylurea. Multiple linear regression analyses revealed associations among uNAG, diabetes duration, and waist circumference. CONCLUSIONS: T2D patients without albuminuria excrete proteinuria and that presence of the protein in urine is associated with uNAG. NAP was positively correlated with T2D duration and waist circumference, but negatively correlated with body mass index. Lean.
Full Text
https://www.sciencedirect.com/science/article/pii/S1056872718308134
DOI
10.1016/j.jdiacomp.2018.09.010
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Lee, Byung Wan(이병완) ORCID logo https://orcid.org/0000-0002-9899-4992
Lee, Yong Ho(이용호) ORCID logo https://orcid.org/0000-0002-6219-4942
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/170025
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