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A phase II study investigating the acute toxicity of targeted intraoperative radiotherapy as tumor-bed boost plus whole breast irradiation after breast-conserving surgery in Korean patients
DC Field | Value | Language |
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dc.contributor.author | 김준원 | - |
dc.contributor.author | 배숭준 | - |
dc.contributor.author | 안성귀 | - |
dc.contributor.author | 윤창익 | - |
dc.contributor.author | 이익재 | - |
dc.contributor.author | 이학우 | - |
dc.contributor.author | 정준 | - |
dc.date.accessioned | 2019-07-11T03:25:43Z | - |
dc.date.available | 2019-07-11T03:25:43Z | - |
dc.date.issued | 2019 | - |
dc.identifier.issn | 0167-6806 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/169970 | - |
dc.description.abstract | BACKGROUND: There are concerns regarding local toxicity when IORT is applied in Asian women with a smaller breast volume than that of Western women. Trials are required to develop safety profiles for this technique. The aim of this trial was to evaluate acute toxicity after intra-operative radiotherapy (IORT) with low-energy X-ray plus whole breast irradiation (WBI) in Asian patients with breast cancer. METHODS: This single-arm, single-institute, phase II trial investigated acute toxicity after completion of radiotherapy (targeted IORT followed by WBI) in Korean patients treated with breast-conserving surgery (BCS). In the conventional WBI arm from the TARGIT-A trial, the incidence of acute toxicity within 6 months was 15%. To prove the non-inferiority of the acute toxicity rate, 215 patients were required. This trial is registered with ClinicalTrials.gov (NCT02213991). RESULTS: Two-hundred and fifteen women were enrolled, and 198 underwent IORT. In 33 patients, clinically significant complications during the acute period were noted. The incidence of acute toxicity was 16.7% (95% CI 11.5-21.9%). There were 29 patients with seroma needing more than 3 aspirations, 4 with wound infection, and 2 with skin breakdown. There was no difference in the rate of complications according to the tumor volume or the tumor-breast volume ratio. Advanced age and high BMI were risk factors for acute complications. CONCLUSIONS: Targeted intra-operative radiotherapy using Intrabeam® is a safe procedure for Korean patients with breast cancer with an acceptable toxicity profile in the acute period. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Kluwer Academic | - |
dc.relation.isPartOf | BREAST CANCER RESEARCH AND TREATMENT | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | A phase II study investigating the acute toxicity of targeted intraoperative radiotherapy as tumor-bed boost plus whole breast irradiation after breast-conserving surgery in Korean patients | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Radiation Oncology (방사선종양학교실) | - |
dc.contributor.googleauthor | Sung Gwe Ahn | - |
dc.contributor.googleauthor | Soong June Bae | - |
dc.contributor.googleauthor | Hak Woo Lee | - |
dc.contributor.googleauthor | Chang Ik Yoon | - |
dc.contributor.googleauthor | Jun Won Kim | - |
dc.contributor.googleauthor | Ik Jae Lee | - |
dc.contributor.googleauthor | Joon Jeong | - |
dc.identifier.doi | 10.1007/s10549-018-5038-x | - |
dc.contributor.localId | A00958 | - |
dc.contributor.localId | A05345 | - |
dc.contributor.localId | A02231 | - |
dc.contributor.localId | A05369 | - |
dc.contributor.localId | A03055 | - |
dc.contributor.localId | A05015 | - |
dc.contributor.localId | A03727 | - |
dc.relation.journalcode | J00403 | - |
dc.identifier.eissn | 1573-7217 | - |
dc.identifier.pmid | 30467660 | - |
dc.identifier.url | https://link.springer.com/article/10.1007%2Fs10549-018-5038-x | - |
dc.subject.keyword | Breast cancer | - |
dc.subject.keyword | Intra-operative radiotherapy | - |
dc.subject.keyword | TARGIT | - |
dc.subject.keyword | Toxicity | - |
dc.subject.keyword | Tumor-bed boost | - |
dc.subject.keyword | Whole breast irradiation | - |
dc.contributor.alternativeName | Kim, Jun Won | - |
dc.contributor.affiliatedAuthor | 김준원 | - |
dc.contributor.affiliatedAuthor | 배숭준 | - |
dc.contributor.affiliatedAuthor | 안성귀 | - |
dc.contributor.affiliatedAuthor | 윤창익 | - |
dc.contributor.affiliatedAuthor | 이익재 | - |
dc.contributor.affiliatedAuthor | 이학우 | - |
dc.contributor.affiliatedAuthor | 정준 | - |
dc.citation.volume | 174 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 157 | - |
dc.citation.endPage | 163 | - |
dc.identifier.bibliographicCitation | BREAST CANCER RESEARCH AND TREATMENT, Vol.174(1) : 157-163, 2019 | - |
dc.identifier.rimsid | 62694 | - |
dc.type.rims | ART | - |
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