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The Pathogenic Effect of Cortactin Tyrosine Phosphorylation in Cutaneous Squamous Cell Carcinoma

Authors
 LIANHUA ZHU  ;  EUNAE CHO  ;  GUOHUA ZHAO  ;  MI RYUNG ROH  ;  ZHENLONG ZHENG 
Citation
 IN VIVO, Vol.33(2) : 393-400, 2019 
Journal Title
 IN VIVO 
ISSN
 0258-851X 
Issue Date
2019
MeSH
Adult ; Aged ; Aged, 80 and over ; Biomarkers, Tumor/genetics* ; Carcinoma, Squamous Cell/genetics* ; Carcinoma, Squamous Cell/pathology ; Cell Line, Tumor ; Cell Movement/genetics ; Cell Proliferation/genetics ; Cortactin/genetics* ; Female ; Gene Expression Regulation, Neoplastic/genetics ; Humans ; Male ; Middle Aged ; RNA, Small Interfering/genetics ; Skin Neoplasms/genetics* ; Skin Neoplasms/pathology ; Transfection
Keywords
Cortactin ; cutaneous squamous cell carcinoma ; molecular biomarker ; oncogenic effect ; phosphorylation
Abstract
BACKGROUND/AIM: Cortactin (CTTN) has been considered a promising molecular prognostic factor in various types of cancers. In this study, we aimed to investigate the role of CTTN in the pathogenesis of cutaneous squamous cell carcinoma (CSCC). MATERIALS AND METHODS: CTTN and phospho-CTTN (p-CTTN) expression was determined in 10 healthy controls and 38 CSCC tissue samples by immunohistochemistry. The influence of CTTN on the biological behavior of CSCC cells was also investigated. RESULTS: p-CTTN expression was significantly increased in CSCC than control samples. In contrast, no significant difference in CTTN expression was found between control and CSCC tissues. Moreover, a significant association was found between recurrence-free survival with p-CTTN expression, but not with CTTN expression. Furthermore, the proliferative, migratory, and invasive abilities of CSCC cells were significantly decreased by CTTN-siRNA transfection. CONCLUSION: CTTN phosphorylation is strongly associated with CSCC pathogenesis and may serve as a molecular biomarker of CSCC.
Files in This Item:
T201901537.pdf Download
DOI
10.21873/invivo.11486
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Dermatology (피부과학교실) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Oral Pathology (구강병리학교실) > 1. Journal Papers
Yonsei Authors
Roh, Mi Ryung(노미령) ORCID logo https://orcid.org/0000-0002-6285-2490
Cho, Eunae(조은애산드라) ORCID logo https://orcid.org/0000-0002-0820-3019
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/169929
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