0 51

Cited 4 times in

Homeostatic Control of Sebaceous Glands by Innate Lymphoid Cells Regulates Commensal Bacteria Equilibrium

 Tetsuro Kobayashi  ;  Benjamin Voisin  ;  Do Young Kim  ;  Elizabeth A. Kennedy  ;  Jay-Hyun Jo  ;  Han-Yu Shih  ;  Amanda Truong  ;  Thomas Doebel  ;  Keiko Sakamoto  ;  Chang-Yi Cui  ;  David Schlessinger  ;  Kazuyo Moro  ;  Susumu Nakae  ;  Keisuke Horiuchi  ;  Jinfang Zhu  ;  Warren J. Leonard  ;  Heidi H. Kong  ;  Keisuke Nagao 
 CELL, Vol.176(5) : 982-997.e16, 2019 
Journal Title
Issue Date
Immune cells and epithelium form sophisticated barrier systems in symbiotic relationships with microbiota. Evidence suggests that immune cells can sense microbes through intact barriers, but regulation of microbial commensalism remain largely unexplored. Here, we uncovered spatial compartmentalization of skin-resident innate lymphoid cells (ILCs) and modulation of sebaceous glands by a subset of RORγt+ ILCs residing within hair follicles in close proximity to sebaceous glands. Their persistence in skin required IL-7 and thymic stromal lymphopoietin, and localization was dependent on the chemokine receptor CCR6. ILC subsets expressed TNF receptor ligands, which limited sebocyte growth by repressing Notch signaling pathway. Consequently, loss of ILCs resulted in sebaceous hyperplasia with increased production of antimicrobial lipids and restricted commensalism of Gram-positive bacterial communities. Thus, epithelia-derived signals maintain skin-resident ILCs that regulate microbial commensalism through sebaceous gland-mediated tuning of the barrier surface, highlighting an immune-epithelia circuitry that facilitates host-microbe symbiosis.
Full Text
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Dermatology (피부과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Do Young(김도영) ORCID logo https://orcid.org/0000-0002-0194-9854
사서에게 알리기


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.