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Prognostic Value of Systemic Inflammatory Indices, NLR, PLR, and MPV, for Predicting 1-Year Survival of Patients Undergoing Cytoreductive Surgery with HIPEC

Authors
 Na Young Kim  ;  Duk-Hee Chun  ;  So Yeon Kim  ;  Nam Kyu Kim  ;  Seung Hyuk Baik  ;  Jung Hwa Hong  ;  Kyung Sub Kim  ;  Cheung-soo Shin 
Citation
 JOURNAL OF CLINICAL MEDICINE, Vol.8(5) : E589, 2019 
Journal Title
 JOURNAL OF CLINICAL MEDICINE 
Issue Date
2019
Keywords
hyperthermic intraperitoneal chemotherapy ; mean platelet volume ; neutrophil to lymphocyte ratio ; platelet to lymphocyte ratio
Abstract
The neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), and mean platelet volume (MPV) have been reported to be associated with the prognosis of various types of tumors. This study evaluated the prognostic value and clinical use of inflammatory markers for predicting 1-year survival in patients undergoing cytoreductive surgery (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC). This retrospective study included 160 patients who underwent CRS with HIPEC between July 2014 and April 2017. Data on NLR, PLR, and MPV were collected preoperatively and on postoperative days (POD) 1, 2, 3, 4, and 5. In a multivariate analysis using a cox proportional hazard regression model, higher values of preoperative NLR and MPV, PLR, and MPV on POD 2, 3, and 5 were associated with reduced 1-year survival after CRS with HIPEC. Patients with increased MPV showed lower rates of 1-year survival following CRS with HIPEC. In addition, elevated preoperative NLR and postoperative PLR were correlated with poor survival. These markers are able to stratify patients by risk profile, which may ultimately improve perioperative management and be helpful in improving outcomes following CRS with HIPEC.
Files in This Item:
T201901417.pdf Download
DOI
10.3390/jcm8050589
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Kyung Sub(김경섭)
Kim, Na Young(김나영) ORCID logo https://orcid.org/0000-0003-3685-2005
Kim, Nam Kyu(김남규) ORCID logo https://orcid.org/0000-0003-0639-5632
Kim, So Yeon(김소연) ORCID logo https://orcid.org/0000-0001-5352-157X
Baik, Seung Hyuk(백승혁) ORCID logo https://orcid.org/0000-0003-4183-2332
Shin, Cheung Soo(신증수) ORCID logo https://orcid.org/0000-0001-7829-8458
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/169882
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