Cited 13 times in
Effects of Different Calcium Silicate Cements on the Inflammatory Response and Odontogenic Differentiation of Lipopolysaccharide-Stimulated Human Dental Pulp Stem Cells
DC Field | Value | Language |
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dc.contributor.author | 김선일 | - |
dc.contributor.author | 김예림 | - |
dc.contributor.author | 김욱성 | - |
dc.contributor.author | 김의성 | - |
dc.date.accessioned | 2019-07-11T03:11:09Z | - |
dc.date.available | 2019-07-11T03:11:09Z | - |
dc.date.issued | 2019 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/169869 | - |
dc.description.abstract | This study aimed to analyze the effects of different calcium silicate cements (CSCs) on the inflammatory response and odontogenic differentiation of lipopolysaccharide-stimulated human dental pulp stem cells. Human dental pulp stem cells (hDPSCs) were stimulated with lipopolysaccharide (LPS) to induce inflammation. These LPS-induced dental pulp stem cells (LDPSCs) were cultured with ProRoot MTA, Biodentine, Retro MTA, and Dycal. Cell viability was evaluated using the Cell Counting Kit-8 assay. Interleukin (IL)-6, IL-8, and transforming growth factor (TGF)-β1 cytokine levels were assessed using the enzyme-linked immunosorbent assay. The expressions of alkaline phosphatase (ALP), osteocalcin, and runt-related transcription factor 2 (RUNX2) were analyzed through real-time polymerase chain reaction. ProRoot MTA, Biodentine, and Retro MTA did not significantly decrease the cell viability of LDPSCs for up to 48 h (p < 0.05). Retro MTA significantly decreased the expression of IL-6 and IL-8 by LDPSCs. ProRoot MTA and Biodentine significantly reduced TGF-β expression by LDPSCs (p < 0.05). Regarding odontogenic differentiation, all CSCs had no effect on ALP expression but increased the production of RUNX2 at 12 h. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | MDPI | - |
dc.relation.isPartOf | MATERIALS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Effects of Different Calcium Silicate Cements on the Inflammatory Response and Odontogenic Differentiation of Lipopolysaccharide-Stimulated Human Dental Pulp Stem Cells | - |
dc.type | Article | - |
dc.contributor.college | College of Dentistry (치과대학) | - |
dc.contributor.department | Dept. of Conservative Dentistry (보존과학교실) | - |
dc.contributor.googleauthor | Minsun Chung | - |
dc.contributor.googleauthor | Sukjoon Lee | - |
dc.contributor.googleauthor | Dongzi Chen | - |
dc.contributor.googleauthor | Ukseong Kim | - |
dc.contributor.googleauthor | Yaelim Kim | - |
dc.contributor.googleauthor | Sunil Kim | - |
dc.contributor.googleauthor | Euiseong Kim | - |
dc.identifier.doi | 10.3390/ma12081259 | - |
dc.contributor.localId | A00556 | - |
dc.contributor.localId | A05723 | - |
dc.contributor.localId | A05724 | - |
dc.contributor.localId | A00833 | - |
dc.relation.journalcode | J02182 | - |
dc.identifier.eissn | 1996-1944 | - |
dc.identifier.pmid | 30999582 | - |
dc.subject.keyword | calcium silicate cement | - |
dc.subject.keyword | human dental pulp stem cell | - |
dc.subject.keyword | inflammation | - |
dc.subject.keyword | lipopolysaccharide | - |
dc.subject.keyword | odontogenic differentiation | - |
dc.contributor.alternativeName | Kim, Sun Il | - |
dc.contributor.affiliatedAuthor | 김선일 | - |
dc.contributor.affiliatedAuthor | 김예림 | - |
dc.contributor.affiliatedAuthor | 김욱성 | - |
dc.contributor.affiliatedAuthor | 김의성 | - |
dc.citation.volume | 12 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | E1259 | - |
dc.identifier.bibliographicCitation | MATERIALS, Vol.12(8) : E1259, 2019 | - |
dc.identifier.rimsid | 62233 | - |
dc.type.rims | ART | - |
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