115 158

Cited 6 times in

COPD as a Disease of Immunosenescence

Authors
 Won-Kyung Cho  ;  Chun Geun Lee  ;  Lark Kyun Kim 
Citation
 YONSEI MEDICAL JOURNAL, Vol.60(5) : 407-413, 2019 
Journal Title
 YONSEI MEDICAL JOURNAL 
ISSN
 0513-5796 
Issue Date
2019
MeSH
Aging/pathology ; Humans ; Immunosenescence* ; Inflammation/pathology ; Lung/pathology ; Pulmonary Disease, Chronic Obstructive/immunology* ; Pulmonary Disease, Chronic Obstructive/physiopathology
Keywords
COPD ; aging ; immunosenescence ; inflammaging ; inflammation
Abstract
Although chronic obstructive pulmonary disease (COPD) is regarded as a chronic inflammatory lung disease, the disease mechanism is still not known. Intriguingly, aging lungs are quite similar to COPD-affected lungs in many ways, and COPD has been viewed as a disease of accelerated premature aging of the lungs. In this paper, based on a literature review, we would like to propose immunosenescence, age-associated decline in immunity, as a critical mechanism for the development of COPD. Immunosenescence can cause a low-grade, systemic inflammation described as inflammaging. This inflammaging may be directly involved in the COPD pathogenesis. The potential contributors to the development of inflammaging in the lungs possibly leading to COPD are discussed in the review paper. A notable fact about COPD is that only 15% to 20% of smokers develop clinically significant COPD. Given that there is a substantial inter-individual variation in inflammaging susceptibility, which is genetically determined and significantly affected by the history of the individual's exposure to pathogens, immunosenescence and inflammaging may also provide the answer for this unexpectedly low susceptibility of smokers to clinically significant COPD.
Files in This Item:
T201901368.pdf Download
DOI
10.3349/ymj.2019.60.5.407
Appears in Collections:
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
Yonsei Authors
Kim, Lark Kyun(김락균) ORCID logo https://orcid.org/0000-0001-5983-4470
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/169855
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse

Links