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Epigenetic memory in gene regulation and immune response

Authors
 Min Young Kim  ;  Ji Eun Lee  ;  Lark Kyun Kim  ;  TaeSoo Kim 
Citation
 BMB REPORTS, Vol.52(2) : 127-132, 2019 
Journal Title
 BMB REPORTS 
ISSN
 1976-6696 
Issue Date
2019
MeSH
Animals ; Chromatin ; Epigenesis, Genetic/genetics* ; Epigenomics/methods ; Galactokinase/genetics ; Galactokinase/physiology ; Gene Expression/genetics ; Gene Expression/physiology ; Gene Expression Regulation/genetics* ; Gene Expression Regulation/physiology* ; Humans ; Regulatory Elements, Transcriptional/genetics ; Regulatory Elements, Transcriptional/physiology
Abstract
Cells must fine-tune their gene expression programs for optimal cellular activities in their natural growth conditions. Transcriptional memory, a unique transcriptional response, plays a pivotal role in faster reactivation of genes upon environmental changes, and is facilitated if genes were previously in an active state. Hyper-activation of gene expression by transcriptional memory is critical for cellular differentiation, development, and adaptation. TREM (Transcriptional REpression Memory), a distinct type of transcriptional memory, promoting hyper-repression of unnecessary genes, upon environmental changes has been recently reported. These two transcriptional responses may optimize specific gene expression patterns, in rapidly changing environments. Emerging evidence suggests that they are also critical for immune responses. In addition to memory B and T cells, innate immune cells are transcriptionally hyperactivated by restimulation, with the same or different pathogens known as trained immunity. In this review, we briefly summarize recent progress in chromatin-based regulation of transcriptional memory, and its potential role in immune responses.
Files in This Item:
T201901367.pdf Download
DOI
10.5483/BMBRep.2019.52.2.257
Appears in Collections:
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
Yonsei Authors
Kim, Lark Kyun(김락균) ORCID logo https://orcid.org/0000-0001-5983-4470
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/169854
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