Cited 9 times in
A Feasibility Study for Diagnosis of Latent Tuberculosis Infection Using an IGRA Point-of-Care Platform in South Korea
DC Field | Value | Language |
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dc.contributor.author | 조상래 | - |
dc.date.accessioned | 2019-07-11T03:01:19Z | - |
dc.date.available | 2019-07-11T03:01:19Z | - |
dc.date.issued | 2019 | - |
dc.identifier.issn | 0513-5796 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/169816 | - |
dc.description.abstract | PURPOSE: This study aimed to evaluate ichroma™ IGRA-TB, a novel point-of-care platform for assaying IFN-γ release, and to compare it with QuantiFERON-TB Gold In-Tube (QFT-GIT) for identifying Mycobacterium tuberculosis (M. tb) infection. MATERIALS AND METHODS: We recruited 60 healthy subjects, and blood samples were obtained in QFT-GIT blood collection tubes. The blood collection tubes were incubated at 37°C, and culture supernatant was harvested after 18-24 hours. IFN-γ responses were assessed by the ichroma™ IGRA-TB cartridge and the QFT-GIT IFN-γ enzyme-linked immunosorbent assay. Three active TB patients were recruited as a positive control for M. tb infection. RESULTS: The area under the receiver operating characteristic curve of the ichroma™ IGRA-TB test for differentiating between infected and non-infected individuals was 0.9706 (p<0.001). Inconsistent positivity between the two tests was found in three participants who showed weak positive IFN-γ responses (<1.0 IU/mL) with QFT-GIT. However, the two tests had excellent agreement (95.2%, κ=0.91, p<0.001), and a very strong positive correlation was observed between the IFN-γ values of both tests (r=0.91, p<0.001). CONCLUSION: The diagnostic accuracy demonstrated in this study indicates that the ichroma™ IGRA-TB test could be used as a rapid diagnostic method for detecting latent TB infection. It may be particularly beneficial in resource-limited places that require cost-effective laboratory diagnostics. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Yonsei University | - |
dc.relation.isPartOf | YONSEI MEDICAL JOURNAL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Area Under Curve | - |
dc.subject.MESH | Case-Control Studies | - |
dc.subject.MESH | Enzyme-Linked Immunosorbent Assay/methods* | - |
dc.subject.MESH | Feasibility Studies | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Interferon-gamma/analysis | - |
dc.subject.MESH | Interferon-gamma/blood* | - |
dc.subject.MESH | Interferon-gamma Release Tests/methods* | - |
dc.subject.MESH | Latent Tuberculosis/diagnosis* | - |
dc.subject.MESH | Latent Tuberculosis/ethnology | - |
dc.subject.MESH | Latent Tuberculosis/immunology | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Mycobacterium tuberculosis/immunology | - |
dc.subject.MESH | Mycobacterium tuberculosis/isolation & purification* | - |
dc.subject.MESH | Point-of-Care Systems* | - |
dc.subject.MESH | ROC Curve | - |
dc.subject.MESH | Reagent Kits, Diagnostic | - |
dc.subject.MESH | Republic of Korea/epidemiology | - |
dc.subject.MESH | Tuberculin Test/methods* | - |
dc.subject.MESH | Young Adult | - |
dc.title | A Feasibility Study for Diagnosis of Latent Tuberculosis Infection Using an IGRA Point-of-Care Platform in South Korea | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Microbiology (미생물학교실) | - |
dc.contributor.googleauthor | Yun-Gyoung Hur | - |
dc.contributor.googleauthor | Ji Young Hong | - |
dc.contributor.googleauthor | Dong Hwan Choi | - |
dc.contributor.googleauthor | Ahreum Kim | - |
dc.contributor.googleauthor | So-yeong Park | - |
dc.contributor.googleauthor | Minsuk Kwon | - |
dc.contributor.googleauthor | Kyungjoon Kang | - |
dc.contributor.googleauthor | Jeong-Min Lee | - |
dc.contributor.googleauthor | Hazel M. Dockrell | - |
dc.contributor.googleauthor | Yoonsuk Lee | - |
dc.contributor.googleauthor | Hoodon Joo | - |
dc.contributor.googleauthor | Sang-Nae Cho | - |
dc.identifier.doi | 10.3349/ymj.2019.60.4.375 | - |
dc.contributor.localId | A03824 | - |
dc.relation.journalcode | J02813 | - |
dc.identifier.eissn | 1976-2437 | - |
dc.identifier.pmid | 30900424 | - |
dc.subject.keyword | IFN-γ | - |
dc.subject.keyword | QuantiFERON-TB Gold In-Tube test | - |
dc.subject.keyword | latent TB infection | - |
dc.subject.keyword | point-of-care platform | - |
dc.subject.keyword | tuberculosis | - |
dc.subject.keyword | ichroma™ IGRA-TB | - |
dc.contributor.alternativeName | Cho, Sang Nae | - |
dc.contributor.affiliatedAuthor | 조상래 | - |
dc.citation.volume | 60 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 375 | - |
dc.citation.endPage | 380 | - |
dc.identifier.bibliographicCitation | YONSEI MEDICAL JOURNAL, Vol.60(4) : 375-380, 2019 | - |
dc.identifier.rimsid | 62399 | - |
dc.type.rims | ART | - |
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