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Chinese liver fluke Clonorchis sinensis infection changes the gut microbiome and increases probiotic Lactobacillus in mice

Authors
 Ju Yeong Kim  ;  Eun-Min Kim  ;  Myung-hee Yi  ;  Jinyoung Lee  ;  Seogwon Lee  ;  Younjee Hwang  ;  Dongeun Yong  ;  Woon-Mok Sohn  ;  Tai-Soon Yong 
Citation
 PARASITOLOGY RESEARCH, Vol.118(2) : 693-699, 2019 
Journal Title
 PARASITOLOGY RESEARCH 
ISSN
 0932-0113 
Issue Date
2019
MeSH
Animals ; Clonorchiasis/immunology* ; Clonorchiasis/parasitology ; Clonorchis sinensis/growth & development ; Clonorchis sinensis/immunology* ; Feces/microbiology ; Gastrointestinal Microbiome/physiology* ; High-Throughput Nucleotide Sequencing ; Lactobacillus/classification ; Lactobacillus/cytology ; Lactobacillus/growth & development* ; Metacercariae/cytology ; Mice ; Mice, Inbred C57BL ; Probiotics/analysis* ; RNA, Ribosomal, 16S/genetics
Keywords
Clonorchis sinensis ; Gut microbiome ; Lactobacillus ; Liver fluke ; Metagenomics
Abstract
Chinese liver fluke Clonorchis sinensis changes the host's immune system. Recently, it has been reported that helminths including C. sinensis can ameliorate immune-related diseases such as allergy. In addition, recent studies showed that helminth infection can alleviate immune-mediated disorders by altering the gut microbiome. However, changes in the gut microbiome due to C. sinensis have not been reported yet. In this study, changes in the gut microbiome of C57BL/6 mice infected with C. sinensis metacercariae were evaluated over time. Stool was analyzed by 16S rRNA amplicon analysis using high-throughput sequencing technology. There was no apparent difference in species richness and diversity between the infected and control groups. However, the composition of the microbiome was different between the infected and control groups at 20 days and 30 days post-infection, and the difference disappeared at 50 days post-infection. In particular, this microbiome alteration was associated with a change in the relative abundance of genus Lactobacillus and the probiotic Lactobacillus species that are known to have an immune-modulation role in immune-mediated diseases.
Full Text
https://link.springer.com/article/10.1007%2Fs00436-018-6179-x
DOI
10.1007/s00436-018-6179-x
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Environmental Medical Biology (환경의생물학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Ju Young(김주영) ORCID logo https://orcid.org/0000-0003-2456-6298
Yong, Dong Eun(용동은) ORCID logo https://orcid.org/0000-0002-1225-8477
Yong, Tai Soon(용태순) ORCID logo https://orcid.org/0000-0002-3445-0769
Yi, Myung Hee(이명희) ORCID logo https://orcid.org/0000-0001-9537-5726
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/169813
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