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Treatment Strategy after Endoscopic Resection of Superficial Esophageal Squamous Cell Carcinoma: A Single Institution Experience

 Hyun Jik Lee  ;  Hyuk Lee  ;  Jun Chul Park  ;  Sung Kwan Shin  ;  Sang Kil Lee  ;  Yong Chan Lee 
 GUT AND LIVER, Vol.9(6) : 714-719, 2015 
Journal Title
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Aged ; Aged, 80 and over ; Antineoplastic Protocols* ; Carcinoma, Squamous Cell/pathology* ; Carcinoma, Squamous Cell/therapy* ; Chemoradiotherapy ; Combined Modality Therapy ; Dissection ; Esophageal Neoplasms/pathology* ; Esophageal Neoplasms/therapy* ; Esophageal Squamous Cell Carcinoma ; Esophagectomy ; Esophagoscopy* ; Female ; Humans ; Male ; Middle Aged ; Mucous Membrane/pathology ; Neoplasm Invasiveness ; Neoplasm Recurrence, Local ; Postoperative Care* ; Postoperative Period ; Retrospective Studies ; Treatment Outcome ; Tumor Burden
Endoscopic resection ; Superficial esophageal squamous cell carcinoma ; Treatment strategy
BACKGROUND/AIMS: The aim of this study was to analyze and propose a treatment strategy after endoscopic resection of superficial esophageal squamous cell carcinoma in a single institution. METHODS: This is a retrospective review of 37 patients who were treated by endoscopic resection during a 6-year period. RESULTS: The mean tumor size was 11.5±5.5 mm (range, 3 to 31 mm). Thirty-one lesions (83.8%) were treated by endoscopic submucosal dissection, and six lesions were treated by endoscopic mucosal resection (16.2%). The en bloc resection rate and complete resection rate were 91.9% and 81.8%, respectively. The tumor invasion depth was diagnosed as epithelial in five cases (13.5%), lamina propria mucosa in 12 cases (32.4%), muscularis mucosa in 10 cases (27.0%) and submucosa in 10 cases (27.0%). The complication rate was 13.5% and included three cases (8.1%) of perforation. Ten patients who had muscularis mucosa and submucosa lesions received additional treatments, including six patients who were treated with esophagectomy, three patients who were treated with radiotherapy and one patient who was treated with chemoradiotherapy. One patient with lamina propria lesions received radiotherapy due to a positive resection margin. The median follow-up duration was 22 months (range, 4 to 79 months), and no recurrence or metastasis was noted during follow-up. CONCLUSIONS: Tailored management after endoscopic treatment of superficial esophageal squamous cell carcinoma can offer an acceptable oncologic outcome in early esophageal carcinoma.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Park, Jun Chul(박준철) ORCID logo https://orcid.org/0000-0001-8018-0010
Song, Si Young(송시영) ORCID logo https://orcid.org/0000-0002-1417-4314
Shin, Sung Kwan(신성관) ORCID logo https://orcid.org/0000-0001-5466-1400
Lee, Sang Kil(이상길) ORCID logo https://orcid.org/0000-0002-0721-0364
Lee, Yong Chan(이용찬) ORCID logo https://orcid.org/0000-0001-8800-6906
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