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Dose-response relationship between radiation dose and loco-regional control in patients with stage II-III esophageal cancer treated with definitive chemoradiotherapy

Other Titles
 근치적 항암화학방사선 병용요법으로 치료받은 2-3기 식도암 환자에서 방사선량과 국소제어율간의 선량-반응관계 
Authors
 김현주 
College
 College of Medicine (의과대학) 
Department
 Dept. of Radiation Oncology (방사선종양학교실) 
 Dept. of Radiation Oncology (방사선종양학교실) 
Degree
석사
Issue Date
2017
Description
의학과/석사
Keywords
Esophageal neoplasms ; Chemoradiotherapy ; Dose-response relationship
Abstract
Purpose: The correlation between radiation dose and loco-regional control (LRC) was
evaluated in patients with stage II–III esophageal cancer treated with definitive
concurrent chemoradiotherapy (CRT).
Materials and Methods: Medical records of 236 stage II–III esophageal cancer
patients treated with definitive CRT at Yonsei Cancer Center between 1994 and 2013
were retrospectively reviewed. Among these, 120 received a radiation dose of <60 Gy
(standard-dose group), while 116 received ≥60 Gy (high-dose group). The median
doses of radiation in the standard- and high-dose groups were 50.4 and 63 Gy,
respectively. Concurrent 5-fluorouracil/cisplatin chemotherapy was administered to
most patients.
2
Results: There were no differences in patient characteristics between the two groups
except for high Karnofsky performance status and lower-thoracic lesions being more
prevalent in the standard-dose group. The median progression-free survival (PFS) and
overall survival (OS) times were 13.2 and 26.2 months, respectively. Patients in the
high-dose group had significantly better 2-year LRC (69.1% vs. 50.3%, P = 0.002),
median PFS (16.7 vs. 11.7 months, P = 0.029), and median OS (35.1 vs. 22.3 months,
P = 0.043). Additionally, LRC exhibited a dose-response relationship and the
complete response rate was significantly higher in the high-dose group (P = 0.006).
There were no significant differences in treatment-related toxicities between the
groups.
Conclusion: A higher radiation dose (>60 Gy) is associated with increased LRC, PFS,
and OS in patients with stage II–III esophageal cancer treated with definitive CRT.
Files in This Item:
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실) > 3. Dissertation
Yonsei Authors
Kim, Hyun Ju(김현주)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/169701
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