Background and Purpose: Rapid administration of intravenous recombinant
tissue plasminogen activator (IV tPA) is an effective way to enhance
thrombolytic efficacy in stroke patients. The process of decision-making by
patients or their families may cause a delay in treatment. We investigated how a
protocol using decision-making support (DMS) for patients and their families
could reduce door-to-needle time in acute stroke.
Methods: We implemented a DMS protocol using a standardized script and
visual decision aid for explanations to patients and their families. Reasons for
delay were identified in cases with door-to-needle time >40 min. We compared
door-to-needle time and reasons for treatment delay before (January 2007 to
December 2009) and after (January 2010 to December 2012) implementation of
the DMS protocol.
2
Results: After the implementation of DMS protocol, median door-to-needle
time was reduced from 46 min to 40 min (p=0.001). The proportion of patients
with door-to-needle time ≤ 40 min was greater after the implementation (64/118
[54.2%] vs. 40/111 [36.0%], p=0.006). The proportion of cases with delay due
to waiting for informed consent was significantly reduced from 32.4 % to 14.8%
(p=0.024). Multivariable logistic regression analysis showed that the
implementation of the DMS protocol was independently associated with door
to-needle time ≤40 min (adjusted odds ratio 2.13, 95% confidence interval 1.23
3.67).
Conclusion: Decision making support for the patient or family’s decision using
standardized scripts and visual aids was helpful in reducing door-to-needle time.
More widespread implementation of this approach is warranted because it is
simpleand can be easily implemented.