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Combining deep-inspiration breath hold and intensity-modulated radiotherapy for gastric mucosa-associated lymphoid tissue lymphoma: Dosimetric evaluation using comprehensive plan quality indices

DC Field Value Language
dc.contributor.author김진성-
dc.contributor.author백종걸-
dc.contributor.author윤홍인-
dc.contributor.author최서희-
dc.date.accessioned2019-05-29T05:23:27Z-
dc.date.available2019-05-29T05:23:27Z-
dc.date.issued2019-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/169572-
dc.description.abstractBACKGROUND: Although there have been many attempts to increase the therapeutic ratio of radiotherapy for gastric mucosa-associated lymphoid tissue lymphoma (MALToma), only a few planning studies have reported the efficacy of the modern radiotherapy technique till date. Therefore, we performed the dosimetric comparison among 3-dimensional conformal radiotherapy (3D-CRT) and intensity-modulated radiotherapy (IMRT) plans, using deep-inspiration breath hold (DIBH) or free-breathing (FB) techniques, to determine the most optimal plan for gastric MALToma. METHODS: We evaluated 9 patients with gastric MALToma for whom 3D-CRT, step-and-shoot IMRT (SIMRT), volumetric-modulated arc therapy (VMAT), and tomotherapy plans with identical prescribed doses were generated using DIBH or FB computed tomography (CT). Planning target volume (PTV) coverage and non-target doses were calculated for each plan and compared with plan quality metric (PQM) scores. RESULTS: All 72 plans of 9 patients satisfied our dosimetric goals, and the IMRT plans and 3D-CRT plans had similarly good conformity index values with no differences related to respiratory movement. IMRT plans yielded significantly better doses to the organs-at-risk, and DIBH plans yielded significantly lower liver, heart, and lung Dmean and spinal cord Dmax with smaller irradiated volumes compared to FB plans. For the mean PQM scores, VMAT-DIBH and SIMRT-DIBH yielded the best scores, whereas 3D plans provided reduced beam monitor unit values. CONCLUSION: Our findings demonstrate that modern RT technologies (DIBH with VMAT or SIMRT) could potentially provide excellent target coverage for gastric MALToma while reducing doses to organs-at-risk. However, the relevance of the most optimal plan considering clinical outcomes should be confirmed further in a larger patient cohort.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherBioMed Central-
dc.relation.isPartOfRADIATION ONCOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleCombining deep-inspiration breath hold and intensity-modulated radiotherapy for gastric mucosa-associated lymphoid tissue lymphoma: Dosimetric evaluation using comprehensive plan quality indices-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Radiation Oncology (방사선종양학교실)-
dc.contributor.googleauthorSeo Hee Choi-
dc.contributor.googleauthorSo Hyun Park-
dc.contributor.googleauthorJason Joon Bock Lee-
dc.contributor.googleauthorJong Geol Baek-
dc.contributor.googleauthorJin Sung Kim-
dc.contributor.googleauthorHong In Yoon-
dc.identifier.doi10.1186/s13014-019-1263-7-
dc.contributor.localIdA04548-
dc.contributor.localIdA05348-
dc.contributor.localIdA04777-
dc.contributor.localIdA04867-
dc.relation.journalcodeJ02591-
dc.identifier.eissn1748-717X-
dc.identifier.pmid30961618-
dc.subject.keywordDeep inspiration breath hold-
dc.subject.keywordIntensity modulated radiotherapy-
dc.subject.keywordMucosa-associated lymphoid tissue lymphoma-
dc.subject.keywordPlanning study-
dc.subject.keywordRadiotherapy-
dc.contributor.alternativeNameKim, Jinsung-
dc.contributor.affiliatedAuthor김진성-
dc.contributor.affiliatedAuthor백종걸-
dc.contributor.affiliatedAuthor윤홍인-
dc.contributor.affiliatedAuthor최서희-
dc.citation.volume14-
dc.citation.number1-
dc.citation.startPage59-
dc.identifier.bibliographicCitationRADIATION ONCOLOGY, Vol.14(1) : 59, 2019-
dc.identifier.rimsid62219-
dc.type.rimsART-
Appears in Collections:
6. Others (기타) > Severance Hospital (세브란스병원) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실) > 1. Journal Papers

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