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CYP2C19 유전자 다형성에 따른 VerifyNow P2Y12 검사와 뇌졸 중 재발 관련성

Other Titles
 Relationship between VerifyNow P2Y12 assay for CYP2C19 polymorphisms and stroke recurrence 
Authors
 한상원  ;  김용재  ;  서우근  ;  유성욱  ;  남효석  ;  윤성상  ;  김서현  ;  이종윤  ;  이준홍  ;  황양하  ;  이준  ;  이경아  ;  이경열 
Citation
 Journal of Vascular Neurology, Vol.3(1) : 16-22, 2018 
Journal Title
Journal of Vascular Neurology
ISSN
 2508-626X 
Issue Date
2018
Keywords
clopidogrel ; polymorphisms ; stroke ; VerifyNow
Abstract
Background and Purpose: To perform a subgroup analysis of MAESTRO study to explore the relationship between VerifyNow P2Y12 assay and stroke recurrence with regard to CYP2C19 polymorphisms. Methods: Patients who underwent clopidogrel treatment and VerifyNow assay in the MAESTRO study were analyzed. For the study, the efficacy and safety of clopidogrel t treatment for the secondary prevention of ischemic stroke and major vascular event were compared based on CYP2C19 polymorphisms and VerifyNow P2Y12 assay. Results:Two hundred fifty-six patients were entered for this subgroup analysis. The median duration of follow-up was 3.0 years. Thirteen (5.1%) patients had a recurrent stroke: 10 (77%) experienced an ischemic stroke and 3 (23%) experienced an intracerebral hemorrhage. In patients with percent inhibition (% INH) ≥40, the risk of recurrent stroke in the good genotype group was 2.0% and was not significantly different from that in the poor genotype group (4.8%) (P=0.536). In patients with % INH <40, there was no reduction in risk for recurrent stroke in the good genotype group (2.2% vs 6.7%, P=0.225). Though there were no significant differences, a trend toward having more number of recurrent ischemic stroke was observed in % INH <40 and poor genotype group. The risk of recurrent ischemic stroke in the % INH ≥40 and good genotype group was 0% and was 6.7% in the % INH <40 and poor genotype group (P=0.06). Conclusions: Ex vivo platelet function test relating to genetic polymorphisms did not predict stroke recurrence during clopidogrel treatment.
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
Yonsei Authors
Nam, Hyo Suk(남효석) ORCID logo https://orcid.org/0000-0002-4415-3995
Lee, Kyung Yul(이경열) ORCID logo https://orcid.org/0000-0001-5585-7739
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/169520
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