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Clinical Implications of Basilar Artery Plaques in the Pontine Infarction with Normal Basilar Angiogram: A High-Resolution Magnetic Resonance Imaging Study

Authors
 Han-Jin Cho  ;  Kyung-Hye Kim  ;  Eun-Joo Kim  ;  Tae Hong Lee  ;  Sang Min Sung  ;  Ji Hoe Heo  ;  Dae Soo Jung 
Citation
 JOURNAL OF STROKE & CEREBROVASCULAR DISEASES, Vol.27(12) : 3591-3598, 2018 
Journal Title
 JOURNAL OF STROKE & CEREBROVASCULAR DISEASES 
ISSN
 1052-3057 
Issue Date
2018
MeSH
Aged ; Aged, 80 and over ; Basilar Artery/diagnostic imaging* ; Brain Stem Infarctions/diagnostic imaging* ; Cerebral Angiography* ; Female ; Humans ; Magnetic Resonance Imaging*/methods ; Male ; Middle Aged ; Plaque, Atherosclerotic/diagnostic imaging* ; Pons/diagnostic imaging* ; Prognosis ; Prospective Studies
Keywords
Stroke ; atherosclerotic plaque ; magnetic resonance imaging ; prognosis.
Abstract
BACKGROUND: Using high-resolution magnetic resonance imaging (HR-MRI), we investigated the impact of basilar artery plaques that were not detected by magnetic resonance angiography (MRA) on the functional outcomes of patients with acute pontine infarction. METHODS: A total of 40 patients with acute pontine infarction and normal basilar findings on MRA prospectively underwent HR-MRI for detection of basilar artery plaques. A relevant plaque was defined as one on the dorsal side of basilar artery, the same side of the ischemic lesion, and the same axial slices of the ischemic lesion. We analyzed the relationship between the relevant basilar artery plaques and the functional outcomes at 3 months. RESULTS: The initial National Institutes of Health Stroke Scale score (3.5 versus 2.0, P = .012), and the incidences of neurological deterioration (42.9% versus 6.3%, P = .031) and unfavorable functional outcome (71.4% versus 12.5%, P = .001) were higher in patients with relevant basilar artery plaques than in those without. On multiple regression analysis, the relevant basilar artery plaque was a significant and independent predictor of unfavorable functional outcome (odds ratio, 6.662; 95% confidence interval, 1.117-39.735; P = .037). CONCLUSIONS: The presence of a relevant basilar artery plaque was closely related with unfavorable functional outcome in patients with acute pontine infarction even if the patients' MRA showed normal basilar findings.
Full Text
https://www.sciencedirect.com/science/article/pii/S1052305718304865
DOI
10.1016/j.jstrokecerebrovasdis.2018.08.032
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
Yonsei Authors
Heo, Ji Hoe(허지회) ORCID logo https://orcid.org/0000-0001-9898-3321
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/169507
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