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Evaluation of nitroglycerin and cyclosporin A sorption to polyvinylchloride- and non-polyvinylchloride-based tubes in administration sets

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dc.contributor.author진수언-
dc.date.accessioned2019-05-29T05:17:24Z-
dc.date.available2019-05-29T05:17:24Z-
dc.date.issued2018-
dc.identifier.issn2093-5552-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/169506-
dc.description.abstractWe report the sorption evaluation method for injectable drugs administered using set tubes to evaluate the quality of the administration sets. The evaluation method using a peristaltic pump, so called pump method, was used for the kinetic sorption study. Nitroglycerin (NTG) and cyclosporin A (CSA) were selected as model drugs. The parameters of drug-diluted concentrations and flow rates were adapted to the clinically relevant values. Polyvinylchloride (PVC)- and non-PVC (PU and PO)-based tubes were cut to a fixed length of 1 m after removing the accessories in the administration sets. NTG and CSA were analyzed using high-performance liquid chromatography (HPLC) methods with ultraviolet (UV) detection. After the drug analyses, NTG and CSA sorption levels were calculated from the percentage values of the subtracted drug concentrations in samples from those in the diluted solutions. The average sorption levels and each sorption level at each sampling point were considered to compare the sorption levels in all administration set tubes. Both drugs showed high sorption levels in PVC- and PU-based administration set tubes. However, the drugs showed a minimum sorption potential of < 10% on PO-based tubes, which could be clinically acceptable. This suggests that the sorption evaluation methods for NTG and CSA could be promising standards for endorsing administration set tubes and for evaluating newly developed or designed polymeric alternatives. Additionally, PO could be an alternative and next-generation polymeric material for manufacturing administration set tubes.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisher한국약제학회-
dc.relation.isPartOfJournal of Pharmaceutical Investigation-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleEvaluation of nitroglycerin and cyclosporin A sorption to polyvinylchloride- and non-polyvinylchloride-based tubes in administration sets-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentOthers-
dc.contributor.googleauthorSu-Eon Jin-
dc.contributor.googleauthorJung Woo Park-
dc.contributor.googleauthorHong Baek-
dc.contributor.googleauthorSeungho Jeon-
dc.contributor.googleauthorSang Wook Park-
dc.contributor.googleauthorSung-Joo Hwang-
dc.identifier.doi10.1007/s40005-017-0364-2-
dc.contributor.localIdA03984-
dc.relation.journalcodeJ01699-
dc.identifier.eissn2093-6214-
dc.identifier.urlhttps://link.springer.com/article/10.1007/s40005-017-0364-2-
dc.subject.keywordSorption evaluation-
dc.subject.keywordAdministration set tube-
dc.subject.keywordPVC-
dc.subject.keywordNon-PVC-
dc.subject.keywordNitroglycerin-
dc.subject.keywordCyclosporin A-
dc.contributor.alternativeNameJin, Su Eon-
dc.contributor.affiliatedAuthor진수언-
dc.citation.volume48-
dc.citation.number6-
dc.citation.startPage665-
dc.citation.endPage672-
dc.identifier.bibliographicCitationJournal of Pharmaceutical Investigation, Vol.48(6) : 665-672, 2018-
Appears in Collections:
1. College of Medicine (의과대학) > Research Institute (부설연구소) > 1. Journal Papers

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