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Association of follow-up infarct volume with functional outcome in acute ischemic stroke: a pooled analysis of seven randomized trials

Authors
 Anna M M Boers  ;  Ivo G H Jansen  ;  Ludo F M Beenen  ;  Thomas G Devlin  ;  Luis San Roman  ;  Ji Hoe Heo  ;  Marc Ribó  ;  Scott Brown  ;  Mohammed A Almekhlafi  ;  David S Liebeskind  ;  Jeanne Teitelbaum  ;  Hester F Lingsma  ;  Wim H van Zwam  ;  Patricia Cuadras  ;  Richard du Mesnil de Rochemont  ;  Marine Beaumont  ;  Martin M Brown  ;  Albert J Yoo  ;  Robert J van Oostenbrugge  ;  Bijoy K Menon  ;  Geoffrey A Donnan  ;  Jean Louis Mas  ;  Yvo B W E M Roos  ;  Catherine Oppenheim  ;  Aad van der Lugt  ;  Richard J Dowling  ;  Michael D Hill  ;  Antoni Davalos  ;  Thierry Moulin  ;  Nelly Agrinier  ;  Andrew M Demchuk  ;  Demetrius K Lopes  ;  Lucia Aja Rodríguez  ;  Diederik W J Dippel  ;  Bruce C V Campbell  ;  Peter J Mitchell  ;  Fahad S Al-Ajlan  ;  Tudor G Jovin  ;  Jeremy Madigan  ;  Gregory W Albers  ;  Sebastien Soize  ;  Francis Guillemin  ;  Vivek K Reddy  ;  Serge Bracard  ;  Jordi Blasco  ;  Keith W Muir  ;  Raul G Nogueira  ;  Phil M White  ;  Mayank Goyal  ;  Stephen M Davis  ;  Henk A Marquering  ;  Charles B L M Majoie 
Citation
 JOURNAL OF NEUROINTERVENTIONAL SURGERY, Vol.10(12) : 1137-1142, 2018 
Journal Title
 JOURNAL OF NEUROINTERVENTIONAL SURGERY 
ISSN
 1759-8478 
Issue Date
2018
MeSH
Aged ; Brain Ischemia/diagnostic imaging* ; Brain Ischemia/therapy ; Cerebral Infarction/diagnostic imaging ; Cerebral Infarction/therapy ; Female ; Follow-Up Studies ; Humans ; Magnetic Resonance Imaging/methods ; Middle Aged ; Randomized Controlled Trials as Topic/methods* ; Recovery of Function/physiology* ; Stroke/diagnostic imaging* ; Stroke/therapy ; Time Factors ; Tomography, X-Ray Computed/methods ; Treatment Outcome
Keywords
brain ; ct ; mri ; stroke ; thrombectomy
Abstract
BACKGROUND: Follow-up infarct volume (FIV) has been recommended as an early indicator of treatment efficacy in patients with acute ischemic stroke. Questions remain about the optimal imaging approach for FIV measurement. OBJECTIVE: To examine the association of FIV with 90-day modified Rankin Scale (mRS) score and investigate its dependency on acquisition time and modality. METHODS: Data of seven trials were pooled. FIV was assessed on follow-up (12 hours to 2 weeks) CT or MRI. Infarct location was defined as laterality and involvement of the Alberta Stroke Program Early CT Score regions. Relative quality and strength of multivariable regression models of the association between FIV and functional outcome were assessed. Dependency of imaging modality and acquisition time (≤48 hours vs >48 hours) was evaluated. RESULTS: Of 1665 included patients, 83% were imaged with CT. Median FIV was 41 mL (IQR 14-120). A large FIV was associated with worse functional outcome (OR=0.88(95% CI 0.87 to 0.89) per 10 mL) in adjusted analysis. A model including FIV, location, and hemorrhage type best predicted mRS score. FIV of ≥133 mL was highly specific for unfavorable outcome. FIV was equally strongly associated with mRS score for assessment on CT and MRI, even though large differences in volume were present (48 mL (IQR 15-131) vs 22 mL (IQR 8-71), respectively). Associations of both early and late FIV assessments with outcome were similar in strength (ρ=0.60(95% CI 0.56 to 0.64) and ρ=0.55(95% CI 0.50 to 0.60), respectively). CONCLUSIONS: In patients with an acute ischemic stroke due to a proximal intracranial occlusion of the anterior circulation, FIV is a strong independent predictor of functional outcome and can be assessed before 48 hours, oneither CT or MRI.
Full Text
https://jnis.bmj.com/content/10/12/1137.long
DOI
10.1136/neurintsurg-2017-013724
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
Yonsei Authors
Heo, Ji Hoe(허지회) ORCID logo https://orcid.org/0000-0001-9898-3321
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/169499
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