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Estimating age group-dependent sensitivity and mean sojourn time in colorectal cancer screening

DC FieldValueLanguage
dc.contributor.author김규리-
dc.contributor.author김윤남-
dc.contributor.author남정모-
dc.contributor.author박소희-
dc.contributor.author정인경-
dc.date.accessioned2019-05-29T05:16:22Z-
dc.date.available2019-05-29T05:16:22Z-
dc.date.issued2019-
dc.identifier.issn0969-1413-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/169496-
dc.description.abstractOBJECTIVE: In evaluating the efficacy of cancer screening programmes, sojourn time (duration of the preclinical detectable phase) and sensitivity of the screening test are the two key parameters. Studies suggest that in breast cancer screening, both parameters may vary depending on age at the time of screening, but few studies have examined other cancers. We expanded an existing probability model for periodic screening by performing simultaneous estimation of age group-dependent and sensitivity at preclinical onset time, and tested the expanded model using data from the Korean National Colorectal Cancer Screening Programme. METHODS: Simulation studies were conducted to assess the performance of the proposed probability model. The method was then applied to the analysis of 376,542 participants aged 50 or over who underwent fecal occult blood testing (FOBT) as part of the National Colorectal Cancer Screening Programme between 2004 and 2007. Age group-dependent mean sojourn time and screening sensitivity of FOBT for colorectal cancer were derived using maximum likelihood estimation. RESULTS: The method performed well in terms of bias, standard deviation, and coverage probability. National Colorectal Cancer Screening Programme data results indicated that the sensitivity of FOBT to detect colorectal cancer increases with age, while mean sojourn time decreases with age (approximately 4.3 years for participants aged 50-54, 3.9 years at age 55-59, 3.4 years at age 60-64, and 3.6 years at age 65-69, with corresponding sensitivity estimates around 41%, 47%, 45%, and 51%, respectively). CONCLUSION: Simulation studies showed that the proposed stochastic model considering both mean sojourn time and sensitivity yields highly accurate results.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherSage-
dc.relation.isPartOfJOURNAL OF MEDICAL SCREENING-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleEstimating age group-dependent sensitivity and mean sojourn time in colorectal cancer screening-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Preventive Medicine and Public Health (예방의학교실)-
dc.contributor.googleauthorNa Young Sung-
dc.contributor.googleauthorJae Kwan Jun-
dc.contributor.googleauthorYoun Nam Kim-
dc.contributor.googleauthorInkyung Jung-
dc.contributor.googleauthorSohee Park-
dc.contributor.googleauthorGyu Ri Kim-
dc.contributor.googleauthorChung Mo Nam-
dc.identifier.doi10.1177/0969141318790775-
dc.contributor.localIdA05300-
dc.contributor.localIdA04535-
dc.contributor.localIdA04535-
dc.contributor.localIdA01264-
dc.contributor.localIdA01264-
dc.contributor.localIdA01531-
dc.contributor.localIdA01531-
dc.contributor.localIdA03693-
dc.contributor.localIdA03693-
dc.relation.journalcodeJ01584-
dc.identifier.eissn1475-5793-
dc.identifier.pmid30261804-
dc.identifier.urlhttps://journals.sagepub.com/doi/full/10.1177/0969141318790775?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%3dpubmed-
dc.subject.keywordBias-
dc.subject.keywordcolorectal cancer-
dc.subject.keywordfaecal occult blood test-
dc.subject.keywordscreening-
dc.subject.keywordsensitivity-
dc.subject.keywordsojourn time-
dc.contributor.alternativeNameKim, Gyu Ri-
dc.contributor.affiliatedAuthor김규리-
dc.contributor.affiliatedAuthor김윤남-
dc.contributor.affiliatedAuthor김윤남-
dc.contributor.affiliatedAuthor남정모-
dc.contributor.affiliatedAuthor남정모-
dc.contributor.affiliatedAuthor박소희-
dc.contributor.affiliatedAuthor박소희-
dc.contributor.affiliatedAuthor정인경-
dc.contributor.affiliatedAuthor정인경-
dc.citation.volume26-
dc.citation.number1-
dc.citation.startPage19-
dc.citation.endPage25-
dc.identifier.bibliographicCitationJOURNAL OF MEDICAL SCREENING, Vol.26(1) : 19-25, 2019-
Appears in Collections:
7. Others (기타) > Gangnam Severance Hospital (강남세브란스병원) > 1. Journal Papers
4. Graduate School of Public Health (보건대학원) > Graduate School of Public Health (보건대학원) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Biomedical Systems Informatics (의생명시스템정보학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Preventive Medicine and Public Health (예방의학교실) > 1. Journal Papers

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