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Validation of a Blood Biomarker for Identification of Individuals at High Risk for Gastric Cancer

Authors
 Meira Epplein  ;  Julia Butt  ;  Yang Zhang  ;  Laura H. Hendrix  ;  Christian C. Abnet  ;  Gwen Murphy  ;  Wei Zheng  ;  Xiao-Ou Shu  ;  Shoichiro Tsugane  ;  You-lin Qiao  ;  Philip R. Taylor  ;  Taichi Shimazu  ;  Keun-Young Yoo  ;  Sue K. Park  ;  Jeongseon Kim  ;  Sun Ha Jee  ;  Tim Waterboer  ;  Michael Pawlita  ;  Wei-cheng You  ;  Kai-feng Pan 
Citation
 CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, Vol.27(12) : 1472-1479, 2018 
Journal Title
 CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION 
ISSN
 1055-9965 
Issue Date
2018
Abstract
BACKGROUND: Helicobacter pylori is the leading cause of gastric cancer, yet the majority of infected individuals will not develop neoplasia. Previously, we developed and replicated serologic H. pylori biomarkers for gastric cancer risk among prospective cohorts in East Asia and now seek to validate the performance of these biomarkers in identifying individuals with premalignant lesions. METHODS: This cross-sectional study included 1,402 individuals from Linqu County screened by upper endoscopy. H. pylori protein-specific antibody levels were assessed using multiplex serology. Multivariable-adjusted logistic regression models were used to calculate odds ratios (ORs) and 95% confidence intervals (CIs) for prevalent intestinal metaplasia, indefinite dysplasia, or dysplasia, compared with superficial or mild atrophic gastritis. RESULTS: Compared with individuals seronegative to Omp and HP0305, individuals seropositive to both were seven times more likely to have precancerous lesions (OR, 7.43; 95% CI, 5.59-9.88). A classification model for precancerous lesions that includes age, smoking, and seropositivity to H. pylori, Omp, and HP0305 resulted in an area under the curve (AUC) of 0.751 (95% CI, 0.725-0.777), which is significantly better than the same model, including the established gastric cancer risk factor CagA (AUC, 0.718; 95% CI, 0.691-0.746, P difference = 0.0002). CONCLUSIONS: The present study of prevalent precancerous gastric lesions provides support for two new serum biomarkers of gastric cancer risk, Omp and HP 0305. IMPACT: Our results support further research into the serological biomarkers Omp and HP0305 as possible improvements over the established virulence marker CagA for identifying individuals with precancerous lesions in East Asia.
Full Text
http://cebp.aacrjournals.org/content/27/12/1472.long
DOI
10.1158/1055-9965.EPI-18-0582
Appears in Collections:
4. Graduate School of Public Health (보건대학원) > Graduate School of Public Health (보건대학원) > 1. Journal Papers
Yonsei Authors
Jee, Sun Ha(지선하) ORCID logo https://orcid.org/0000-0001-9519-3068
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/169397
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