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Role of Agmatine on Neuroglia in Central Nervous System Injury.

DC FieldValueLanguage
dc.contributor.author김종열-
dc.contributor.author이종은-
dc.date.accessioned2019-05-29T05:05:51Z-
dc.date.available2019-05-29T05:05:51Z-
dc.date.issued2019-
dc.identifier.issn1976-8753-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/169395-
dc.description.abstractRecovery from central nervous system (CNS) injury, such as stroke or spinal cord injury (SCI), largely depends on axonal regeneration, and the neuronal and glial cells plasticity in the lesioned tissue. The lesioned tissue following CNS injury forms a scar that is composed of astrocytes and mixed with connective tissues. At the glial scar, the regenerating axon forms dystrophic endbulbs which do not regenerate and grow beyond the glial scar without a suitable environment. Along with the astrocytes, microglia are also suspected of being involved in necrotic and apoptotic neuronal cell death and the early response to axonal damage in CNS injury. The inflammatory response, a major component of secondary injury and controlled by the microglia, plays a pivotal role in nerve injury and control the regenerative response. As a result, it is very important to control the glial cell function in order to assure the recovery of the CNS injury. Studies have suggested that agmatine, a L-arginine derived primary amine, is a potential modulator of glial cell function after CNS injuries. Agmatine was found to possess anti-inflammatory and neuroprotective characteristics that benefited the rehabilitation process following CNS injury. In this review, we will discuss the effect of agmatine on glial cells in the process of recovery after CNS injury.-
dc.description.statementOfResponsibilityopen-
dc.publisherKorean Society for Neurorehabilitation-
dc.relation.isPartOfBrain & Neurorehabilitation-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleRole of Agmatine on Neuroglia in Central Nervous System Injury.-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Anatomy (해부학교실)-
dc.contributor.googleauthorSumit Barua-
dc.contributor.googleauthorJong Youl Kim-
dc.contributor.googleauthorJong Eun Lee-
dc.identifier.doi10.12786/bn.2019.12.e2-
dc.contributor.localIdA00923-
dc.contributor.localIdA03146-
dc.contributor.localIdA03146-
dc.relation.journalcodeJ00387-
dc.subject.keywordAgmatine-
dc.subject.keywordAstrocyte-
dc.subject.keywordMicroglia-
dc.subject.keywordGlia-
dc.subject.keywordCNS Injury-
dc.contributor.alternativeNameKim, Jong Youl-
dc.contributor.affiliatedAuthor김종열-
dc.contributor.affiliatedAuthor이종은-
dc.contributor.affiliatedAuthor이종은-
dc.citation.volume12-
dc.citation.number1-
dc.citation.startPagee2-
dc.identifier.bibliographicCitationBrain & Neurorehabilitation, Vol.12(1) : e2, 2019-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anatomy (해부학교실) > 1. Journal Papers

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