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Hypothalamic inflammation and obesity: a mechanistic review

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dc.contributor.author김기우-
dc.date.accessioned2019-05-29T05:03:28Z-
dc.date.available2019-05-29T05:03:28Z-
dc.date.issued2019-
dc.identifier.issn0253-6269-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/169369-
dc.description.abstractObesity is one of the worldwide prevalent disease caused by the imbalance between food intake and energy expenditure. Over a 100 years of research demonstrate that hypothalamus is the critical brain region regulating energy homeostasis, and evidences suggest the participation of non-neuronal populations such as astrocytes and microglia in the regulation of energy homeostasis. Recently, fat-rich diet induced hypothalamic inflammation has been found to deregulate the energy homeostasis, leading to the insulin resistance, glucose intolerance, and obesity. Several underlying mechanisms have been proposed, yet compelling evidences require further elucidations. This review discusses the up to date proposed mechanisms by which fat-rich diet induces hypothalamic inflammation and obesity.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherPharmaceutical Society of Korea-
dc.relation.isPartOfARCHIVES OF PHARMACAL RESEARCH-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleHypothalamic inflammation and obesity: a mechanistic review-
dc.typeArticle-
dc.contributor.collegeCollege of Dentistry (치과대학)-
dc.contributor.departmentDept. of Oral Biology (구강생물학교실)-
dc.contributor.googleauthorJichang Seong-
dc.contributor.googleauthorJung Yun Kang-
dc.contributor.googleauthorJi Su Sun-
dc.contributor.googleauthorKi Woo Kim-
dc.identifier.doi10.1007/s12272-019-01138-9-
dc.contributor.localIdA05301-
dc.relation.journalcodeJ00229-
dc.identifier.pmid30835074-
dc.identifier.urlhttps://link.springer.com/article/10.1007%2Fs12272-019-01138-9-
dc.subject.keywordAstrocyte-
dc.subject.keywordHypothalamus-
dc.subject.keywordInflammation-
dc.subject.keywordMicroglia-
dc.subject.keywordObesity-
dc.contributor.alternativeNamekim, KiWoo-
dc.contributor.affiliatedAuthor김기우-
dc.citation.volume42-
dc.citation.number5-
dc.citation.startPage383-
dc.citation.endPage392-
dc.identifier.bibliographicCitationARCHIVES OF PHARMACAL RESEARCH, Vol.42(5) : 383-392, 2019-
dc.identifier.rimsid62083-
dc.type.rimsART-
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실) > 1. Journal Papers

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