Cited 6 times in
Wound healing mechanism in Mongolian gerbil skin
DC Field | Value | Language |
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dc.contributor.author | 이동준 | - |
dc.contributor.author | 정한성 | - |
dc.date.accessioned | 2019-04-03T07:50:49Z | - |
dc.date.available | 2019-04-03T07:50:49Z | - |
dc.date.issued | 2019 | - |
dc.identifier.issn | 0948-6143 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/167767 | - |
dc.description.abstract | The skin wound healing ability of animals differs depending on the environment. The gerbil wound model showed a different wound healing mechanism than was known thus far. Many other wound healing mechanisms have been found to involve transforming growth factor-beta 1 (TGF-β1). However, in the wound healing of gerbil skin, the expression of TGF-β1 seems to be not enough compared to mouse. In this study, we compared the wound healing process of gerbil and mouse back skin. At 3 days after wounding, the TGF-β1 level was downregulated in gerbil skin wound healing compared mouse. In addition, gerbils have fewer integrin signals related to the regulation of TGF-β activation and signaling. Despite lacking these factors, the wound healing results in the gerbil are similar to those for skin wound healing in mice. In contrast, in gerbil skin wound healing, the basal skin layer showed hyperplasia in re-epithelialization, more production of hair follicles, and low probability of collagen infiltration at the late stages of wound healing. These data suggest that different wound healing mechanisms are present in the mammals. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Springer | - |
dc.relation.isPartOf | HISTOCHEMISTRY AND CELL BIOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Wound healing mechanism in Mongolian gerbil skin | - |
dc.type | Article | - |
dc.contributor.college | College of Dentistry (치과대학) | - |
dc.contributor.department | Dept. of Oral Biology (구강생물학교실) | - |
dc.contributor.googleauthor | Min-Jung Lee | - |
dc.contributor.googleauthor | Dong‑Joon Lee | - |
dc.contributor.googleauthor | Han-Sung Jung | - |
dc.identifier.doi | 10.1007/s00418-018-1752-z | - |
dc.contributor.localId | A02732 | - |
dc.contributor.localId | A03758 | - |
dc.relation.journalcode | J00992 | - |
dc.identifier.eissn | 1432-119X | - |
dc.identifier.pmid | 30392058 | - |
dc.identifier.url | https://link.springer.com/article/10.1007%2Fs00418-018-1752-z | - |
dc.contributor.alternativeName | Lee, Dong Joon | - |
dc.contributor.affiliatedAuthor | 이동준 | - |
dc.contributor.affiliatedAuthor | 정한성 | - |
dc.citation.volume | 151 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 229 | - |
dc.citation.endPage | 238 | - |
dc.identifier.bibliographicCitation | HISTOCHEMISTRY AND CELL BIOLOGY, Vol.151(3) : 229-238, 2019 | - |
dc.identifier.rimsid | 58364 | - |
dc.type.rims | ART | - |
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