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Clinical Evaluation of a Low-pain Long Microneedle for Subcutaneous Insulin Injection

Authors
 Ghunil Lee  ;  Yonghao Ma  ;  Yong-ho Lee  ;  Hyungil Jung 
Citation
 Biochip Journal, Vol.12(4) : 309-316, 2018 
Journal Title
 Biochip Journal 
ISSN
 1976-0280 
Issue Date
2018
Keywords
Microneedle ; Insulin ; Subcutaneous injection ; Pain ; Bleeding ; Pharmacodynamic profile
Abstract
Microneedles (MNs) are being developed to overcome the limitations of the conventional hypodermic needle, e.g. the injection pain. In this study, we conducted an analysis of clinical pain and bleeding at the site of MN insertion and evaluated the insulin pharmacodynamic profile compared with parameters obtained with a conventional pen needle. MN insertion into the skin of 25 healthy adults or 15 patients with type 2 diabetes (T2D) revealed significantly less pain relative to a conventional hypodermic pen needle, thus reducing pain scores from 2.1±1.9 to 1.3±1.4 (mean±standard deviation [SD]). Besides, no bleeding was observed when the MN was used. In the insulin pharmacodynamic assay, no significant differences were observed in the blood glucose-lowering effect between the pen needle and MN. Based on these results, the MN is expected to be a good substitute for conventional hypodermic pen needles and improve the quality of life of patients by significantly reducing the pain associated with insulin treatment.
Full Text
https://link.springer.com/article/10.1007%2Fs13206-018-2411-0
DOI
10.1007/s13206-018-2411-0
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
이용호(Lee, Yong Ho) ORCID logo https://orcid.org/0000-0002-6219-4942
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/167749
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