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Local injection of RANKL facilitates tooth movement and alveolar bone remodelling

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dc.contributor.author이기준-
dc.contributor.author정주령-
dc.contributor.author황충주-
dc.date.accessioned2019-03-15T02:37:05Z-
dc.date.available2019-03-15T02:37:05Z-
dc.date.issued2019-
dc.identifier.issn1354-523X-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/167614-
dc.description.abstractOBJECTIVES: To investigate the effect of local injection of receptor activator of nuclear factor kappa B ligand (RANKL) on experimental tooth movement and subsequent alveolar bone remodelling in mice. MATERIALS AND METHODS: Sixty mice were randomised to receive daily local RANKL or phosphate-buffered saline injections in the buccal premaxillary bone for 14 of 21 days of incisor movement, followed by a 21-day retention period. Five mice from each group were euthanised on days 0, 3, 7, 14, 21 and 42, and specimens were prepared for haematoxylin and eosin, tartrate-resistant acid phosphatase and immunohistochemical staining. Five mice from each group were subjected to serial microcomputed tomography until day 42 for tooth movement and bone volume quantification. RESULTS: The experimental group showed significantly greater tooth movement and bone volume reduction on days 14 and 21; an increased osteoclast number on days 3, 7, 14 and 21; and no difference on day 42. Higher RANKL expression was observed on days 7 and 14, with remarkable alkaline phosphatase activity. No significant systemic changes were observed. CONCLUSION: Local RANKL injection leads to increased osteoclastic activity and facilitates tooth movement, followed by subsequent alveolar bone formation; this implies a reversible transitional acceleration of bone resorption.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherMunksgaard-
dc.relation.isPartOfORAL DISEASES-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleLocal injection of RANKL facilitates tooth movement and alveolar bone remodelling-
dc.typeArticle-
dc.contributor.collegeCollege of Dentistry (치과대학)-
dc.contributor.departmentDept. of Orthodontics (교정과학교실)-
dc.contributor.googleauthorChengri Li-
dc.contributor.googleauthorChooryung J. Chung-
dc.contributor.googleauthorChung‐Ju Hwang-
dc.contributor.googleauthorKee‐Joon Lee-
dc.identifier.doi10.1111/odi.13013-
dc.contributor.localIdA02698-
dc.contributor.localIdA03724-
dc.contributor.localIdA04492-
dc.relation.journalcodeJ02438-
dc.identifier.eissn1601-0825-
dc.identifier.pmid30536847-
dc.identifier.urlhttps://onlinelibrary.wiley.com/doi/full/10.1111/odi.13013-
dc.subject.keywordbone remodelling-
dc.subject.keywordlocal injection-
dc.subject.keywordmicrocomputed tomography-
dc.subject.keywordreceptor activator of nuclear factor kappa B ligand-
dc.subject.keywordtooth movement-
dc.contributor.alternativeNameLee, Kee Joon-
dc.contributor.affiliatedAuthor이기준-
dc.contributor.affiliatedAuthor정주령-
dc.contributor.affiliatedAuthor황충주-
dc.citation.volume25-
dc.citation.number2-
dc.citation.startPage550-
dc.citation.endPage560-
dc.identifier.bibliographicCitationORAL DISEASES, Vol.25(2) : 550-560, 2019-
dc.identifier.rimsid61033-
dc.type.rimsART-
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Orthodontics (교정과학교실) > 1. Journal Papers

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