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High-dose versus standard-dose radiation therapy for cervical esophageal cancer: Retrospective single-institution study

Authors
 Tae Hyung Kim  ;  Ik Jae Lee  ;  Ji‐Hyun Kim  ;  Chang Geol Lee  ;  Yong Chan Lee  ;  Jun Won Kim 
Citation
 Head & Neck, Vol.41(1) : 146-153, 2019 
Journal Title
 Head & Neck 
ISSN
 1043-3074 
Issue Date
2019
Keywords
cervical esophageal carcinoma ; chemoradiation ; dose escalation
Abstract
BACKGROUND: To evaluate the role of definitive radiotherapy using higher-than-standard-dose radiation of 50 Gy for carcinoma of the cervical esophagus (CCE). METHODS: We reviewed 79 patients with stage I-III CCE, treated between 2000 and 2012. Patients received 5-fluorouracil/cisplatin-based chemotherapy concurrently and were divided into high-dose (≥59.4 Gy, n = 44) and standard-dose (<59.4 Gy, n = 35) groups. RESULTS: The median follow-up was 35 months for surviving patients. The high-dose group had significantly better 3-year local (90.0% vs 60.4%, P = .001) and locoregional (70.4% vs 45.3%, P = .04) control. Progression-free (45.4% vs 37.5%, P = .32) and overall (58.4% vs 49.1%, P = .69) survival rates were not different. High-dose radiation was an independent prognostic factor for locoregional control (P = .04). No differences in late toxicities (esophageal stenosis or tracheoesophageal fistula) were observed. CONCLUSION: High-dose radiation for CCE improves local and locoregional control, without increasing severe toxicities.
Full Text
https://onlinelibrary.wiley.com/doi/full/10.1002/hed.25483
DOI
10.1002/hed.25483
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Jun Won(김준원) ORCID logo https://orcid.org/0000-0003-1358-364X
Kim, Jie-Hyun(김지현) ORCID logo https://orcid.org/0000-0002-9198-3326
Lee, Yong Chan(이용찬) ORCID logo https://orcid.org/0000-0001-8800-6906
Lee, Ik Jae(이익재) ORCID logo https://orcid.org/0000-0001-7165-3373
Lee, Chang Geol(이창걸) ORCID logo https://orcid.org/0000-0002-8702-881X
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/167510
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