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Assessment of within-breath impulse oscillometry parameters in children with asthma

Authors
 In Suk Sol  ;  Yoon Hee Kim  ;  SooYeon Kim  ;  Jong Deok Kim  ;  Sun Ha Choi  ;  Kyung Won Kim  ;  Myung Hyun Sohn 
Citation
 Pediatric Pulmonology, Vol.54(2) : 117-124, 2019 
Journal Title
 Pediatric Pulmonology 
ISSN
 8755-6863 
Issue Date
2019
Keywords
asthma ; impulse oscillometry ; within-breath analysis
Abstract
BACKGROUND: Impulse oscillometry (IOS) measures respiratory resistance and reactance during tidal breaths and is a convenient tool for evaluation of lung function. Respiratory resistance and reactance can be measured separately during inspiration and expiration (inspiratory-expiratory analysis). OBJECTIVE: We investigated the differences in inspiratory-expiratory measurements obtained using IOS between children with and without asthma. METHODS: We analyzed 819 subjects aged 4-18 years, including asthmatic children (n = 600) and controls (n = 219). Asthma was diagnosed in accordance with the American Thoracic Society/European Respiratory Society guideline. Spirometry and IOS were performed in all subjects. RESULTS: In whole-breath analysis, the asthma group had higher resistance at 5 Hz (R5) and reactance area (AX) and lower reactance at 5 Hz (X5) than the control groups. In inspiratory-expiratory analysis, the asthma group showed increased expiratory R5 and AX and decreased expiratory X5 when compared with the control group. The absolute changes in R5, X5, and AX values between inspiration and expiration were greater in children with asthma than those in controls (0.138 ± 0.195 vs 0.102 ± 0.162, P = 0.014; -0.106 ± 0.200 vs -0.086 ± 0.434, P < 0.001 and 0.460 ± 11.63 vs 0.398 ± 2.88, P = 0.002, respectively). CONCLUSIONS: Inspiratory-expiratory IOS analysis differentiated asthmatic children from control subjects, reflecting airway narrowing on expiration in pediatric asthma. The changes in R5, X5, and AX between inspiration and expiration can be a useful index for diagnosis of asthma in children without assessment of the response to a bronchodilator.
Full Text
https://onlinelibrary.wiley.com/doi/full/10.1002/ppul.24201
DOI
10.1002/ppul.24201
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실) > 1. Journal Papers
Yonsei Authors
김경원(Kim, Kyung Won) ORCID logo https://orcid.org/0000-0003-4529-6135
김수연(Kim, Soo Yeon) ORCID logo https://orcid.org/0000-0003-4965-6193
김윤희(Kim, Yoon Hee) ORCID logo https://orcid.org/0000-0002-2149-8501
김종덕(Kim, Jong Deok)
설인숙(Sol, In Suk) ORCID logo https://orcid.org/0000-0003-2470-9682
손명현(Sohn, Myung Hyun) ORCID logo https://orcid.org/0000-0002-2478-487X
최선하(Choi, Sun Ha)
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/167466
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