0 64

Cited 0 times in

Yersinia pseudotuberculosis Exploits CD209 Receptors for Promoting Host Dissemination and Infection

Authors
 Ying-Xia He  ;  Cheng-Lin Ye  ;  Pei Zhang  ;  Qiao Li  ;  Chae Gyu Park  ;  Kun Yang  ;  Ling-Yu Jiang  ;  Yin Lv  ;  Xiao-Ling Ying  ;  Hong-Hui Ding  ;  Hong-Ping Huang  ;  John Mambwe Tembo  ;  An-Yi Li  ;  Bing Cheng  ;  Shu-Sheng Zhang  ;  Guo-Xing Zheng  ;  Shi-Yun Chen  ;  Wei Li  ;  Lian-Xu Xia  ;  Biao Kan  ;  Xin Wang  ;  Huai-Qi Jing  ;  Rui-Fu Yang  ;  Hua Peng  ;  Yang-Xin Fu  ;  John D. Klena  ;  Mikael Skurnik  ;  Tie Chen 
Citation
 Infection and Immunity, Vol.87(1) : e00654-18, 2019 
Journal Title
 Infection and Immunity 
ISSN
 0019-9567 
Issue Date
2019
Keywords
CD209a ; CD209b ; DC-SIGN ; DCs ; LPS core ; SIGN-R1 ; Yersinia pseudotuberculosis ; dendritic cells ; dissemination ; lipopolysaccharide core
Abstract
Yersinia pseudotuberculosis is a Gram-negative enteropathogen and causes gastrointestinal infections. It disseminates from gut to mesenteric lymph nodes (MLNs), spleen, and liver of infected humans and animals. Although the molecular mechanisms for dissemination and infection are unclear, many Gram-negative enteropathogens presumably invade the small intestine via Peyer's patches to initiate dissemination. In this study, we demonstrate that Y. pseudotuberculosis utilizes its lipopolysaccharide (LPS) core to interact with CD209 receptors, leading to invasion of human dendritic cells (DCs) and murine macrophages. These Y. pseudotuberculosis-CD209 interactions result in bacterial dissemination to MLNs, spleens, and livers of both wild-type and Peyer's patch-deficient mice. The blocking of the Y. pseudotuberculosis-CD209 interactions by expression of O-antigen and with oligosaccharides reduces infectivity. Based on the well-documented studies in which HIV-CD209 interaction leads to viral dissemination, we therefore propose an infection route for Y. pseudotuberculosis where this pathogen, after penetrating the intestinal mucosal membrane, hijacks the Y. pseudotuberculosis-CD209 interaction antigen-presenting cells to reach their target destinations, MLNs, spleens, and livers.
Full Text
https://iai.asm.org/content/87/1/e00654-18.long
DOI
10.1128/IAI.00654-18
Appears in Collections:
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
Yonsei Authors
박채규(Park, Chae Gyu) ORCID logo https://orcid.org/0000-0003-1906-1308
Export
RIS (EndNote)
XLS (Excel)
XML
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/167353
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse