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Senescent T Cells Predict the Development of Hyperglycemia in Humans

 Yong-ho Lee  ;  So Ra Kim  ;  Dai Hoon Han  ;  Hee Tae Yu  ;  Yoon Dae Han  ;  Jin Hee Kim  ;  Soo Hyun Kim  ;  Chan Joo Lee  ;  Byoung-Hoon Min  ;  Dong-Hyun Kim  ;  Kyung Hwan Kim  ;  Jin Won Cho  ;  Won-Woo Lee  ;  Eui-Cheol Shin  ;  Sungha Park 
 Diabetes, Vol.68(1) : 156-162, 2019 
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Senescent T cells have been implicated in chronic inflammatory and cardiovascular diseases. In this study, we explored the relationship between senescent T cells and glycemic status in a cohort of 805 participants by investigating the frequency of CD57+ or CD28null senescent T cells in peripheral blood. Participants with normal glucose tolerance (NGT) with follow-up data (N = 149) were included to determine whether hyperglycemia (prediabetes or type 2 diabetes) developed during follow-up (mean 2.3 years). CD8+CD57+ and CD8+CD28null T-cell frequencies were significantly higher in prediabetes and type 2 diabetes compared with NGT. Increased CD57+ or CD28null cells in the CD8+ T-cell subset were independently associated with hyperglycemia. Furthermore, among participants with baseline NGT, the frequency of CD8+CD57+ T cells was an independent predictor of hyperglycemia development. Immunofluorescent analyses confirmed that CD8+CD57+ T-cell infiltration was increased in visceral adipose tissue of patients with prediabetes or type 2 diabetes compared with those with NGT. Our data suggest that increased frequency of senescent CD8+ T cells in the peripheral blood is associated with development of hyperglycemia.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
김소라(Kim, So Ra)
박성하(Park, Sung Ha) ORCID logo https://orcid.org/0000-0001-5362-478X
유희태(Yu, Hee Tae) ORCID logo https://orcid.org/0000-0002-6835-4759
이용호(Lee, Yong Ho) ORCID logo https://orcid.org/0000-0002-6219-4942
한대훈(Han, Dai Hoon) ORCID logo https://orcid.org/0000-0003-2787-7876
한윤대(Han, Yoon Dae) ORCID logo https://orcid.org/0000-0002-2136-3578
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