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Impact of Micrometastatic Axillary Nodes on Survival of Breast Cancer Patients with Tumors ≤2 츠

 Hyeon Woo Bae  ;  Kwang Hyun Yoon  ;  Joo Heung Kim  ;  Sung Mook Lim  ;  Jee Ye Kim  ;  Hyung Seok Park  ;  Seho Park  ;  Seung Il Kim  ;  Young Up Cho  ;  Byeong-Woo Park 
 World Journal of Surgery, Vol.42(12) : 3969-3978, 2018 
Journal Title
 World Journal of Surgery 
Issue Date
Adult ; Aged ; Axilla ; Breast Neoplasms/mortality ; Breast Neoplasms/pathology* ; Female ; Humans ; Lymphatic Metastasis/pathology ; Middle Aged ; Neoplasm Micrometastasis*/pathology ; Retrospective Studies
BACKGROUND: This study investigated the impact of pN1mi disease on the survival of T1 breast cancer patients and examined the clinical usefulness of the online PREDICT tool and updated staging system. METHODS: The node stages of 2344 patients were divided into pN0, pN1mi, and pN1a. Clinicopathological parameters and survival outcomes were retrospectively analyzed. Data for 111 micrometastatic diseases were applied to the PREDICT version 2.0 and re-classified using the 8th edition of the cancer staging manual. RESULTS: Univariable analyses demonstrated worse disease-free and overall survival rates for patients with node-positive cancer; however, the significance was not maintained in multivariable analyses. Chemotherapy improved outcomes in patients with node-positive and non-luminal A-like subtype cancers. The PREDICT tool demonstrated good performance when estimating the 5-year overall survival for pN1mi disease (area under the receiver operating characteristic curve, 0.834). According to the updated staging system, 74% of cases were down-staged to IA, and clearly splitting survival curves were identified. CONCLUSION: pN1mi disease alone did not adversely affect survival outcomes. Biologic and treatment factors determined outcomes in cases of small-volume node micrometastasis. The PREDICT tool or new staging classification could help predict the survival of patients with micrometastatic sentinel nodes.
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1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
김승일(Kim, Seung Il)
김지예(Kim, Jee Ye) ORCID logo https://orcid.org/0000-0003-3936-4410
박병우(Park, Byeong Woo) ORCID logo https://orcid.org/0000-0003-1353-2607
박세호(Park, Se Ho) ORCID logo https://orcid.org/0000-0001-8089-2755
박형석(Park, Hyung Seok) ORCID logo https://orcid.org/0000-0001-5322-6036
윤광현(Yoon, Kwang Hyun)
조영업(Cho, Young Up) ORCID logo https://orcid.org/0000-0003-2936-410X
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