Cited 4 times in

Impact of Micrometastatic Axillary Nodes on Survival of Breast Cancer Patients with Tumors ≤2 cm

Authors
 Hyeon Woo Bae  ;  Kwang Hyun Yoon  ;  Joo Heung Kim  ;  Sung Mook Lim  ;  Jee Ye Kim  ;  Hyung Seok Park  ;  Seho Park  ;  Seung Il Kim  ;  Young Up Cho  ;  Byeong-Woo Park 
Citation
 WORLD JOURNAL OF SURGERY, Vol.42(12) : 3969-3978, 2018 
Journal Title
WORLD JOURNAL OF SURGERY
ISSN
 0364-2313 
Issue Date
2018
MeSH
Adult ; Aged ; Axilla ; Breast Neoplasms/mortality ; Breast Neoplasms/pathology* ; Female ; Humans ; Lymphatic Metastasis/pathology ; Middle Aged ; Neoplasm Micrometastasis*/pathology ; Retrospective Studies
Abstract
BACKGROUND: This study investigated the impact of pN1mi disease on the survival of T1 breast cancer patients and examined the clinical usefulness of the online PREDICT tool and updated staging system.

METHODS: The node stages of 2344 patients were divided into pN0, pN1mi, and pN1a. Clinicopathological parameters and survival outcomes were retrospectively analyzed. Data for 111 micrometastatic diseases were applied to the PREDICT version 2.0 and re-classified using the 8th edition of the cancer staging manual.

RESULTS: Univariable analyses demonstrated worse disease-free and overall survival rates for patients with node-positive cancer; however, the significance was not maintained in multivariable analyses. Chemotherapy improved outcomes in patients with node-positive and non-luminal A-like subtype cancers. The PREDICT tool demonstrated good performance when estimating the 5-year overall survival for pN1mi disease (area under the receiver operating characteristic curve, 0.834). According to the updated staging system, 74% of cases were down-staged to IA, and clearly splitting survival curves were identified.

CONCLUSION: pN1mi disease alone did not adversely affect survival outcomes. Biologic and treatment factors determined outcomes in cases of small-volume node micrometastasis. The PREDICT tool or new staging classification could help predict the survival of patients with micrometastatic sentinel nodes.
Full Text
https://link.springer.com/article/10.1007%2Fs00268-018-4725-4
DOI
10.1007/s00268-018-4725-4
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Seung Il(김승일)
Kim, Joo Heung(김주흥) ORCID logo https://orcid.org/0000-0002-0417-8434
Kim, Jee Ye(김지예) ORCID logo https://orcid.org/0000-0003-3936-4410
Park, Byeong Woo(박병우) ORCID logo https://orcid.org/0000-0003-1353-2607
Park, Se Ho(박세호) ORCID logo https://orcid.org/0000-0001-8089-2755
Park, Hyung Seok(박형석) ORCID logo https://orcid.org/0000-0001-5322-6036
Yoon, Kwang Hyun(윤광현)
Cho, Young Up(조영업) ORCID logo https://orcid.org/0000-0003-2936-410X
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/167309
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